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dc.contributor.authorOftedal, Linn Silje Wathneen_US
dc.contributor.authorSelheim, Frodeen_US
dc.contributor.authorWahlsten, Mattien_US
dc.contributor.authorSivonen, Kaarinaen_US
dc.contributor.authorDøskeland, Stein Oveen_US
dc.contributor.authorHerfindal, Larsen_US
dc.date.accessioned2016-08-09T07:33:49Z
dc.date.available2016-08-09T07:33:49Z
dc.date.issued2010-10-14
dc.PublishedMarine Drugs 2010, 8(10):2659-2672eng
dc.identifier.issn1660-3397
dc.identifier.urihttps://hdl.handle.net/1956/12500
dc.description.abstractThe potential of marine benthic cyanobacteria as a source of anticancer drug candidates was assessed in a screen for induction of cell death (apoptosis) in acute myeloid leukemia (AML) cells. Of the 41 marine cyanobacterial strains screened, more than half contained cell death-inducing activity. Several strains contained activity against AML cells, but not against non-malignant cells like hepatocytes and cardiomyoblasts. The apoptotic cell death induced by the various strains could be distinguished by the role of caspase activation and sensitivity to the recently detected chemotherapy-resistance-associated prosurvival protein LEDGF/p75. One strain (M44) was particularly promising since its activity counteracted the protective effect of LEDGF/p75 overexpressed in AML cells, acted synergistically with the anthracycline anticancer drug daunorubicin in AML cells, and protected cardiomyoblasts against the toxic effect of anthracyclines. We conclude that culturable benthic marine cyanobacteria from temperate environments provide a promising and hitherto underexploited source for novel antileukemic drugs.en_US
dc.language.isoengeng
dc.publisherMDPIeng
dc.rightsAttribution CC BYeng
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/eng
dc.subjectAMLeng
dc.subjectcyanobacteriaeng
dc.subjectapoptosiseng
dc.subjectCancereng
dc.subjectleukemiaeng
dc.titleMarine Benthic Cyanobacteria Contain Apoptosis-Inducing Activity Synergizing with Daunorubicin to Kill Leukemia Cells, but not Cardiomyocytesen_US
dc.typePeer reviewed
dc.typeJournal article
dc.date.updated2016-04-08T11:15:30Z
dc.description.versionpublishedVersionen_US
dc.rights.holderCopyright 2010 by the authors
dc.identifier.doihttps://doi.org/10.3390/md8102659
dc.identifier.cristin349775
dc.subject.nsiVDP::Medisinske fag: 700::Basale medisinske, odontologiske og veterinærmedisinske fag: 710::Farmakologi: 728
dc.subject.nsiVDP::Midical sciences: 700::Basic medical, dental and veterinary sciences: 710::Pharmacology: 728


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