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dc.contributor.authorNacu, Alionaen_US
dc.contributor.authorBringeland, Gerd Hagaen_US
dc.contributor.authorKhanevski, Andrejen_US
dc.contributor.authorThomassen, Larsen_US
dc.contributor.authorWaje-Andreassen, Ulrikeen_US
dc.contributor.authorNæss, Halvoren_US
dc.date.accessioned2016-08-31T07:33:54Z
dc.date.available2016-08-31T07:33:54Z
dc.date.issued2016-01
dc.PublishedActa Neurologica Scandinavica 2016, 133(1):25-29eng
dc.identifier.issn0001-6314
dc.identifier.urihttps://hdl.handle.net/1956/12694
dc.description.abstractObjectives: Neurological worsening in acute ischaemic stroke patients is common with significant morbidity and mortality. Aims: To determine the factors associated with early neurological worsening within the first 9 h after onset of acute ischaemic stroke. Materials & methods: The National Institute of Health Stroke Scale (NIHSS) was used to assess stroke severity. Early neurological worsening was defined as NIHSS score increase ≥4 NIHSS points within 9 h of symptom onset compared to NIHSS score within 3 h of symptom onset. Patients with early neurological worsening were compared to patients with unchanged or improved NIHSS scores. Results: Of the 2484 patients admitted with ischaemic stroke, 552 patients had NIHSS score within 3 h of symptom onset, and 44 (8.0%) experienced early neurological worsening. The median NIHSS on admission was 8.4 in both groups. Early neurological worsening was associated with low body temperature on admission (P = 0.01), proximal compared to distal MCA occlusion (P = 0.007) and with ipsilateral internal carotid artery stenosis >50% or occlusion (P = 0.04). Early neurological worsening was associated with higher NIHSS day 7 (P < 0.001) and higher mortality within 7 days of stroke onset (P = 0.005). Conclusions: Early neurological worsening has serious consequences for the short-term outcome for patients with acute ischaemic stroke and is associated with low body temperature on admission, and with extracranially and intracranially large-vessel stenosis or occlusion.en_US
dc.language.isoengeng
dc.publisherWileyeng
dc.rightsAttribution-NonCommercial CC BY-NCeng
dc.rights.urihttp://creativecommons.org/licenses/by-nc/4.0/eng
dc.subjectacute ischaemic stroke
dc.subjectbody temperature
dc.subjectearly neurological worsening
dc.titleEarly neurological worsening in acute ischaemic stroke patientsen_US
dc.typePeer reviewed
dc.typeJournal article
dc.date.updated2016-08-24T11:59:10Z
dc.description.versionpublishedVersionen_US
dc.rights.holderCopyright 2015 The Authors
dc.identifier.doihttps://doi.org/10.1111/ane.12418
dc.identifier.cristin1365040


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