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dc.contributor.authorMeyer, Haakon Een_US
dc.contributor.authorStøer, Nathalieen_US
dc.contributor.authorSamuelsen, Sven Oveen_US
dc.contributor.authorBlomhoff, Runeen_US
dc.contributor.authorRobsahm, Trude Eiden_US
dc.contributor.authorBrustad, Magritten_US
dc.contributor.authorGiovannucci, Edward Len_US
dc.contributor.authorBjørge, Toneen_US
dc.date.accessioned2016-09-30T07:48:37Z
dc.date.available2016-09-30T07:48:37Z
dc.date.issued2016-03-17
dc.PublishedPLoS ONE 2016, 11(3)eng
dc.identifier.issn1932-6203
dc.identifier.urihttps://hdl.handle.net/1956/12889
dc.description.abstractObjective A number of observational studies have shown an inverse association between circulating 25-hydroxyvitamin D and total mortality, but a reverse J-shaped association has also been reported. In a large nested case-control study, serum-25-hydroxyvitamin D (s-25(OH)D) was positively associated with incident prostate cancer. Based on the same study population, the primary aim of the present study was to investigate the association between s-25 (OH)D and total mortality. Methods Men participating in population based health screenings during 1981–1991 and enrolled in a nested case-control study were followed throughout 2007 with respect to all-cause and cause-specific mortality. Hazard ratios (HR) with 95% confidence intervals (CI) were calculated using Cox proportional hazards regression. Results In men with prostate cancer (n = 2282), there was a significant inverse association between s-25(OH)D and total mortality after controlling for potential confounders (HR = 1.25 (95% CI 1.05–1.50), s-25(OH)D < 50 nmol/l versus s-25(OH)D > 50 nmol/l). The corresponding figure among controls (n = 2147) was HR = 1.15 (95% CI 0.88–1.50) and in the total study.population HR = 1.19 (95% CI 1.03–1.38). For cause-specific deaths, we found no significant associations. Conclusions In this study population, s-25(OH)D was inversely associated with total mortality during more than two decades of follow-up, despite, as previous reported, high s-25(OH)D was associated with increased risk of prostate cancer.en_US
dc.language.isoengeng
dc.publisherPloseng
dc.relation.urihttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC4795600/pdf/pone.0151441.pdf
dc.rightsAttribution CC BYeng
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/eng
dc.titleLong Term Association between Serum 25-Hydroxyvitamin D and Mortality in a Cohort of 4379 Menen_US
dc.typePeer reviewed
dc.typeJournal article
dc.date.updated2016-07-11T08:46:29Z
dc.description.versionpublishedVersionen_US
dc.rights.holderCopyright 2016 the authors
dc.identifier.doihttps://doi.org/10.1371/ journal.pone.0151441
dc.identifier.cristin1367350


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