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dc.contributor.authorWatne, Leiv Ottoen_US
dc.contributor.authorIdland, Ane-Victoriaen_US
dc.contributor.authorFekkes, Durken_US
dc.contributor.authorRæder, Johanen_US
dc.contributor.authorFrihagen, Frede Jonen_US
dc.contributor.authorRanhoff, Anette Hylenen_US
dc.contributor.authorChaudhry, Farrukh Abbasen_US
dc.contributor.authorEngedal, Knuten_US
dc.contributor.authorWyller, Torgeir Bruunen_US
dc.contributor.authorHassel, Bjørnaren_US
dc.PublishedBMC Geriatrics 2016, 16:149eng
dc.description.abstractBackground: To examine whether delirium in hip fracture patients was associated with changes in the levels of amino acids and/or monoamine metabolites in cerebrospinal fluid (CSF) and serum. Methods: In this prospective cohort study, 77 patients admitted with an acute hip fracture to Oslo University Hospital, Norway, were studied. The concentrations of amino acids in CSF and serum were determined by high performance liquid chromatography. The patients were assessed daily for delirium by the Confusion Assessment Method (pre-operatively and post-operative day 1–5 (all) or until discharge (delirious patients)). Pre-fracture dementia status was decided by an expert panel. Serum was collected pre-operatively and CSF immediately before spinal anesthesia. Results: Fifty-three (71 %) hip fracture patients developed delirium. In hip fracture patients without dementia (n = 39), those with delirium had significantly higher CSF levels of tryptophan (40 % higher), tyrosine (60 % higher), phenylalanine (59 % higher) and the monoamine metabolite 5-hydroxyindoleacetate (23 % higher) compared to those without delirium. The same amino acids were also higher in CSF in delirious patients with dementia (n = 38). The correlations between serum and CSF amino acid levels were poor. Conclusion: Higher CSF levels of monoamine precursors in hip fracture patients with delirium suggest a higher monoaminergic activity in the central nervous system during delirium in this patient group.en_US
dc.publisherBioMed Centraleng
dc.rightsAttribution CC BYeng
dc.titleIncreased CSF levels of aromatic amino acids in hip fracture patients with delirium suggests higher monoaminergic activityen_US
dc.typePeer reviewed
dc.typeJournal article
dc.rights.holderCopyright 2016 The Authors

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