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dc.contributor.authorGansmo, Liv Beatheen_US
dc.contributor.authorBjørnslett, Merete Paulineen_US
dc.contributor.authorHalle, Mari Kyllesøen_US
dc.contributor.authorSalvesen, Helga Birgitteen_US
dc.contributor.authorDørum, Anneen_US
dc.contributor.authorBirkeland, Einar Elvbakkenen_US
dc.contributor.authorHveem, Kristianen_US
dc.contributor.authorRomundstad, Pål Richarden_US
dc.contributor.authorVatten, Lars Johanen_US
dc.contributor.authorLønning, Per Eysteinen_US
dc.contributor.authorKnappskog, Stianen_US
dc.date.accessioned2017-03-30T13:47:13Z
dc.date.available2017-03-30T13:47:13Z
dc.date.issued2016-02-11
dc.PublishedTumour Biology 2016, 37(8):10697-10702eng
dc.identifier.issn1010-4283
dc.identifier.urihttps://hdl.handle.net/1956/15623
dc.description.abstractThe MDM4 protein (also known as MDMX or HDMX) is a negative regulator of p53, not only by direct interaction but also through its interaction with MDM2. Further, MDM4 overexpression and amplification have been observed in several cancer forms. Recently, a single nucleotide polymorphism (SNP) in the 3’ untranslated region of the MDM4 gene, SNP34091A > C (rs4245739) was reported to alter MDM4 messenger RNA (mRNA) stability by modulating a microRNA binding site, thereby leading to decreased MDM4 levels. In this case-control study, we aimed to evaluate the possible association between MDM4 SNP34091 status and cancer risk by comparing the genotype frequencies in large hospital-based cohorts of endometrial- (n = 1404) and ovarian (n = 1385) cancer patients with healthy female controls (n = 1870). Genotype frequencies were compared by odds ratio (OR) estimates and Fisher exact tests. We found that individuals harboring the MDM4 SNP34091AC/CC genotypes had a significantly elevated risk for serous ovarian cancer (SOC) in general and high-grade serous ovarian cancer (HGSOC) in particular (SOC: OR = 1.18., 95 % CI = 1.01–1.39; HGSOC: OR = 1.25, CI = 1.02–1.53). No association between SNP34091 genotypes and endometrial cancer risk was observed. Our data indicate the MDM4 SNP34091AC/CC genotypes to be associated with an elevated risk for SOC and in particular the HGSOC type.en_US
dc.language.isoengeng
dc.publisherSpringereng
dc.rightsAttribution CC BYeng
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/eng
dc.subjectMDM4eng
dc.subjectSNP34091eng
dc.subjectCancer riskeng
dc.subjectOvarian cancereng
dc.subjectEndometrial cancereng
dc.titleThe MDM4 SNP34091 (rs4245739) C-allele is associated with increased risk of ovarian—but not endometrial canceren_US
dc.typePeer reviewed
dc.typeJournal article
dc.date.updated2016-12-13T14:15:37Z
dc.description.versionpublishedVersionen_US
dc.rights.holderCopyright 2016 the authors
dc.identifier.doihttps://doi.org/10.1007/s13277-016-4940-2


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