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dc.contributor.authorBrevik, Erlend Joramo
dc.contributor.authorvan Donkelaar, Marjolein M J
dc.contributor.authorWeber, Heike
dc.contributor.authorSanchez-Mora, Cristina
dc.contributor.authorJacob, Christian
dc.contributor.authorRivero, Olga
dc.contributor.authorKittel-Schneider, Sarah
dc.contributor.authorGarcia-Martinez, Iris
dc.contributor.authorAebi, Marcel
dc.contributor.authorvan Hulzen, Kimm
dc.contributor.authorCormand, Bru
dc.contributor.authorRamos-Quiroga, Josep A
dc.contributor.authorLesch, Klaus-Peter
dc.contributor.authorReif, Andreas
dc.contributor.authorRibases, Marta
dc.contributor.authorFranke, Barbara
dc.contributor.authorPosserud, Maj-Britt Rocio
dc.contributor.authorJohansson, Stefan
dc.contributor.authorLundervold, Astri
dc.contributor.authorHaavik, Jan
dc.contributor.authorZayats, Tetyana
dc.PublishedAmerican Journal of Medical Genetics Part B: Neuropsychiatric Genetics 2016, 171(5):733-747eng
dc.description.abstractAggressiveness is a behavioral trait that has the potential to be harmful to individuals and society. With an estimated heritability of about 40%, genetics is important in its development. We performed an exploratory genome-wide association (GWA) analysis of childhood aggressiveness in attention deficit hyperactivity disorder (ADHD) to gain insight into the underlying biological processes associated with this trait. Our primary sample consisted of 1,060 adult ADHD patients (aADHD). To further explore the genetic architecture of childhood aggressiveness, we performed enrichment analyses of suggestive genome-wide associations observed in aADHD among GWA signals of dimensions of oppositionality (defiant/vindictive and irritable dimensions) in childhood ADHD (cADHD). No single polymorphism reached genome-wide significance (P < 5.00E-08). The strongest signal in aADHD was observed at rs10826548, within a long noncoding RNA gene (beta = −1.66, standard error (SE) = 0.34, P = 1.07E-06), closely followed by rs35974940 in the neurotrimin gene (beta = 3.23, SE = 0.67, P = 1.26E-06). The top GWA SNPs observed in aADHD showed significant enrichment of signals from both the defiant/vindictive dimension (Fisher's P-value = 2.28E-06) and the irritable dimension in cADHD (Fisher's P-value = 0.0061). In sum, our results identify a number of biologically interesting markers possibly underlying childhood aggressiveness and provide targets for further genetic exploration of aggressiveness across psychiatric disordersen_US
dc.rightsAttribution CC BY NCeng
dc.titleGenome-wide analyses of aggressiveness in attention-deficit hyperactivity disordereng
dc.typePeer reviewed
dc.typeJournal article
dc.rights.holderCopyright 2016 the authorseng

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