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dc.contributor.authorFanidi, Anouaren_US
dc.contributor.authorMuller, David C.en_US
dc.contributor.authorMidttun, Øivinden_US
dc.contributor.authorUeland, Per Magneen_US
dc.contributor.authorVollset, Stein Emilen_US
dc.contributor.authorRelton, Carolineen_US
dc.contributor.authorVineis, Paoloen_US
dc.contributor.authorWeiderpass, Elisabeteen_US
dc.contributor.authorSkeie, Gurien_US
dc.contributor.authorBrustad, Magritten_US
dc.contributor.authorPalli, Domenicoen_US
dc.contributor.authorTumino, Rosarioen_US
dc.contributor.authorGrioni, Saraen_US
dc.contributor.authorSacerdote, Carlottaen_US
dc.contributor.authorBueno-de-Mesquita, H. Basen_US
dc.contributor.authorPeeters, Petra H.en_US
dc.contributor.authorBoutron-Ruault, Marie-Christineen_US
dc.contributor.authorKvaskoff, Marinaen_US
dc.contributor.authorCadeau, Claireen_US
dc.contributor.authorHuerta, José Maríaen_US
dc.contributor.authorSánchez, María-Joséen_US
dc.contributor.authorAgudo, Antonioen_US
dc.contributor.authorLasheras, Cristinaen_US
dc.contributor.authorQuirós, J. Ramónen_US
dc.contributor.authorChamosa, Saioaen_US
dc.contributor.authorRiboli, Elioen_US
dc.contributor.authorTravis, Ruth Cen_US
dc.contributor.authorWard, Heatheren_US
dc.contributor.authorMurphy, Neilen_US
dc.contributor.authorKhaw, Kay-Teeen_US
dc.contributor.authorTrichopoulou, Antoniaen_US
dc.contributor.authorLagiou, Pagonaen_US
dc.contributor.authorPapatesta, Eleni-Mariaen_US
dc.contributor.authorBoeing, Heineren_US
dc.contributor.authorKühn, Tilmanen_US
dc.contributor.authorKatzke, Verenaen_US
dc.contributor.authorSteffen, Annikaen_US
dc.contributor.authorJohansson, Andersen_US
dc.contributor.authorBrennan, Paulen_US
dc.contributor.authorJohansson, Mattiasen_US
dc.PublishedFanidi A, Muller DC, Midttun Ø, Ueland PM, Vollset SE, Relton C, Vineis P, Weiderpass E, Skeie G, Brustad M, Palli D, Tumino R, Grioni S, Sacerdote C, Bueno-de-Mesquita HB, Peeters PH, Boutron-Ruault M, Kvaskoff M, Cadeau C, Huerta JM, Sánchez M, Agudo A, Lasheras C, Quirós JR, Chamosa S, Riboli E, Travis RC, Ward H, Murphy N, Khaw K, Trichopoulou A, Lagiou P, Papatesta E, Boeing H, Kühn T, Katzke V, Steffen A, Johansson A, Brennan P, Johansson M. Circulating Vitamin D in relation to cancer incidence and survival of the head and neck and oesophagus in the EPIC cohort. Scientific Reports. 2016;6:36017eng
dc.description.abstractExperimental and epidemiological data suggest that vitamin D play a role in pathogenesis and progression of cancer, but prospective data on head and neck cancer (HNC) and oesophagus cancer are limited. The European Prospective Investigation into Cancer and Nutrition (EPIC) study recruited 385,747 participants with blood samples between 1992 and 2000. This analysis includes 497 case-control pairs of the head and neck and oesophagus, as well as 443 additional controls. Circulating 25(OH)D3 were measured in pre-diagnostic samples and evaluated in relation to HNC and oesophagus cancer risk and post-diagnosis all-cause mortality. After controlling for risk factors, a doubling of 25(OH)D3 was associated with 30% lower odds of HNC (OR 0.70, 95% confidence interval [95% CI] 0.56–0.88, Ptrend = 0.001). Subsequent analyses by anatomical sub-site indicated clear inverse associations with risk of larynx and hypopharynx cancer combined (OR 0.55, 95CI% 0.39–0.78) and oral cavity cancer (OR 0.60, 95CI% 0.42–0.87). Low 25(OH)D3 concentrations were also associated with higher risk of death from any cause among HNC cases. No clear association was seen with risk or survival for oesophageal cancer. Study participants with elevated circulating concentrations of 25(OH)D3 had decreased risk of HNC, as well as improved survival following diagnosis.en_US
dc.publisherNature Publishing Groupeng
dc.rightsAttribution CC BYeng
dc.titleCirculating Vitamin D in relation to cancer incidence and survival of the head and neck and oesophagus in the EPIC cohorten_US
dc.typePeer reviewed
dc.typeJournal article
dc.rights.holderCopyright 2016 The Author(s)
dc.source.journalScientific Reports

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