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dc.contributor.authorBrix, Maiken Kirkegaarden_US
dc.contributor.authorErsland, Larsen_US
dc.contributor.authorHugdahl, Kennethen_US
dc.contributor.authorGrüner, Renateen_US
dc.contributor.authorPosserud, Maj-Britt Rocioen_US
dc.contributor.authorHammar, Åsaen_US
dc.contributor.authorCraig-Craven, Alexander Richarden_US
dc.contributor.authorNoeske, Ralphen_US
dc.contributor.authorEvans, C. Johnen_US
dc.contributor.authorWalker, Hanne Bjørg Hansenen_US
dc.contributor.authorMidtvedt, Toreen_US
dc.contributor.authorBeyer, Mona K.en_US
dc.date.accessioned2017-08-01T13:16:35Z
dc.date.available2017-08-01T13:16:35Z
dc.date.issued2015-06-22
dc.PublishedBrix MK, Ersland L, Hugdahl K, Grüner R, Posserud M, Hammar Å, Craig-Craven A, Noeske, Evans, Walker HBH, Midtvedt T, Beyer MK. Brain MR spectroscopy in autism spectrum disorder—the GABA excitatory/inhibitory imbalance theory revisited. Frontiers in Human Neuroscience. 2015;9:365eng
dc.identifier.issn1662-5161
dc.identifier.urihttps://hdl.handle.net/1956/16165
dc.description.abstractMagnetic resonance spectroscopy (MRS) from voxels placed in the left anterior cingulate cortex (ACC) was measured from 14 boys with Autism Spectrum Disorder (ASD) and 24 gender and age-matched typically developing (TD) control group. Our main aims were to compare the concentration of γ-aminobutyric acid (GABA) between the two groups, and to investigate the relationship between brain metabolites and autism symptom severity in the ASD group. We did find a significant negative correlation in the ASD group between Autism Spectrum Screening Questionnaire (ASSQ) and GABA+/Cr, which may imply that severity of symptoms in ASD is associated with differences in the level of GABA in the brain, supporting the excitatory/inhibitory (E/I) imbalance theory. However we did not find a significant difference between the two groups in GABA levels.en_US
dc.language.isoengeng
dc.publisherFrontierseng
dc.rightsAttribution CC BYeng
dc.rights.urihttp://creativecommons.org/licenses/by/4.0eng
dc.subjectASDeng
dc.subjectGABAeng
dc.subjectMRSeng
dc.subjectMEGA-PRESSeng
dc.subjectASSQeng
dc.titleBrain MR spectroscopy in autism spectrum disorder—the GABA excitatory/inhibitory imbalance theory revisiteden_US
dc.typePeer reviewed
dc.typeJournal article
dc.date.updated2017-05-03T12:06:04Z
dc.description.versionpublishedVersionen_US
dc.rights.holderCopyright 2015 The Author(s)
dc.identifier.doihttps://doi.org/10.3389/fnhum.2015.00365
dc.identifier.cristin1256151
dc.source.journalFrontiers in Human Neuroscience
dc.relation.projectNorges forskningsråd: 223273


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