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dc.contributor.authorWatson, Martin Men_US
dc.contributor.authorLea, Dordien_US
dc.contributor.authorRewcastle, Emmaen_US
dc.contributor.authorHagland, Hanne Rølanden_US
dc.contributor.authorSøreide, Kjetilen_US
dc.date.accessioned2017-08-03T08:59:13Z
dc.date.available2017-08-03T08:59:13Z
dc.date.issued2016-07
dc.PublishedWatson MMC, Lea D, Rewcastle, Hagland H, Søreide K. Elevated microsatellite alterations at selected tetranucleotides in early-stage colorectal cancers with and without high-frequency microsatellite instability: same, same but different?. Cancer Medicine. 2016;5(7):1580-1587eng
dc.identifier.issn2045-7634
dc.identifier.urihttps://hdl.handle.net/1956/16190
dc.description.abstractMicrosatellite instability (MSI) is associated with better prognosis in colorectal cancer (CRC). Elevated microsatellite alterations at selected tetranucleotides (EMAST) is a less-understood form of MSI. Here, we aim to investigate the role of EMAST in CRC±MSI related to clinical and tumor-specific characteristics. A consecutive, population-based series of stage I–III colorectal cancers were investigated for MSI and EMAST using PCR primers for 10 microsatellite markers. Of 151 patients included, 33 (21.8%) had MSI and 35 (23.2%) were EMAST+, with an overlap of 77% for positivity, (odds ratio [OR] 61; P < 0.001), and 95% for both markers being negative. EMAST was more prevalent in colon versus rectum (86% vs. 14%, P = 0.004). EMAST+ cancers were significantly more frequent in proximal colon (77 vs. 23%, P = 0.004), had advanced t-stage (T3–4 vs. T1–2 in 94% vs. 6%, respectively; P = 0.008), were larger (≥5 cm vs. <5 cm in 63% and 37%, respectively; P = 0.022) and had poorly differentiated tumor grade (71 vs. 29%, P < 0.01). Furthermore, EMAST+ tumors had a higher median number of harvested lymph nodes than EMAST− (11 vs. 9 nodes; P = 0.03). No significant association was found between EMAST status and age, gender, presence of distant metastases or metastatic lymph nodes, and overall survival. A nonsignificant difference toward worse survival in node-negative colon cancers needs confirmation in larger cohorts. EMAST+ cancers overlap and share features with MSI+ in CRC. Overall, survival was not influenced by the presence of EMAST, but may be of importance in subgroups such as node-negative disease of the colon.en_US
dc.language.isoengeng
dc.publisherWileyeng
dc.rightsAttribution CC BYeng
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/eng
dc.subjectColorectal cancereng
dc.subjectelevated microsatellite alterationseng
dc.subjectmicrosatellite instabilityeng
dc.subjectnode statuseng
dc.subjectSurvivaleng
dc.titleElevated microsatellite alterations at selected tetranucleotides in early-stage colorectal cancers with and without high-frequency microsatellite instability: same, same but different?en_US
dc.typePeer reviewed
dc.typeJournal article
dc.date.updated2017-05-08T09:55:26Z
dc.description.versionpublishedVersionen_US
dc.rights.holderCopyright 2016 The Author(s)
dc.identifier.doihttps://doi.org/10.1002/cam4.709
dc.identifier.cristin1429089
dc.source.journalCancer Medicine


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