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dc.contributor.authorBlumbach, Katrinen_US
dc.contributor.authorNiehoff, Anjaen_US
dc.contributor.authorBelgardt, Bengt F.en_US
dc.contributor.authorEhlen, Harald W.A.en_US
dc.contributor.authorSchmitz, Markusen_US
dc.contributor.authorHallinger, Ralfen_US
dc.contributor.authorSchulz, Jan-Niklasen_US
dc.contributor.authorBrüning, Jens C.en_US
dc.contributor.authorKrieg, Thomasen_US
dc.contributor.authorSchubert, Markusen_US
dc.contributor.authorGullberg, Donalden_US
dc.contributor.authorEckes, Beateen_US
dc.date.accessioned2017-09-15T13:21:42Z
dc.date.available2017-09-15T13:21:42Z
dc.date.issued2012-02
dc.PublishedBlumbach, Niehoff, Belgardt, Ehlen, Schmitz, Hallinger R, Schulz, Brüning, Krieg T, Schubert, Gullberg D, Eckes B. Dwarfism in mice lacking collagen-binding integrins alpha 2 beta 1 and alpha 11 beta 1 is caused by severely diminished IGF-1 levels. Journal of Biological Chemistry. 2012;287(9):6431-6440eng
dc.identifier.issn0021-9258
dc.identifier.issn1083-351X
dc.identifier.urihttps://hdl.handle.net/1956/16641
dc.description.abstractMice with a combined deficiency in the α2β1 and α11β1 integrins lack the major receptors for collagen I. These mutants are born with inconspicuous differences in size but develop dwarfism within the first 4 weeks of life. Dwarfism correlates with shorter, less mineralized and functionally weaker bones that do not result from growth plate abnormalities or osteoblast dysfunction. Besides skeletal dwarfism, internal organs are correspondingly smaller, indicating proportional dwarfism and suggesting a systemic cause for the overall size reduction. In accordance with a critical role of insulin-like growth factor (IGF)-1 in growth control and bone mineralization, circulating IGF-1 levels in the sera of mice lacking either α2β1 or α11β1 or both integrins were sharply reduced by 39%, 64%, or 81% of normal levels, respectively. Low hepatic IGF-1 production resulted from diminished growth hormone-releasing hormone expression in the hypothalamus and, subsequently, reduced growth hormone expression in the pituitary glands of these mice. These findings point out a novel role of collagen-binding integrin receptors in the control of growth hormone/IGF-1-dependent biological activities. Thus, coupling hormone secretion to extracellular matrix signaling via integrins represents a novel concept in the control of endocrine homeostasis.en_US
dc.language.isoengeng
dc.publisherThe American Society for Biochemistry and Molecular Biologyeng
dc.titleDwarfism in mice lacking collagen-binding integrins alpha 2 beta 1 and alpha 11 beta 1 is caused by severely diminished IGF-1 levelsen_US
dc.typePeer reviewed
dc.typeJournal article
dc.date.updated2017-08-11T20:22:29Z
dc.description.versionpublishedVersionen_US
dc.rights.holderCopyright 2012 by The American Society for Biochemistry and Molecular Biology, Inc
dc.identifier.doihttps://doi.org/10.1074/jbc.m111.283119
dc.identifier.cristin926813
dc.source.journalJournal of Biological Chemistry
dc.relation.projectNorges forskningsråd: 197066
dc.subject.nsiVDP::Medisinske fag: 700::Basale medisinske, odontologiske og veterinærmedisinske fag: 710::Medisinsk biokjemi: 726
dc.subject.nsiVDP::Midical sciences: 700::Basic medical, dental and veterinary sciences: 710::Medical biochemistry: 726


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