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DeNovoGUI: an open source graphical user interface for de novo sequencing of tandem mass spectra

Muth, Thilo; Weilnböck, Lisa; Rapp, Erdmann; Huber, Christian G.; Martens, Lennart; Vaudel, Marc; Barsnes, Harald
Peer reviewed, Journal article
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URI
https://hdl.handle.net/1956/16686
Date
2014
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  • Department of Biomedicine [447]
Original version
https://doi.org/10.1021/pr4008078
Abstract
De novo sequencing is a popular technique in proteomics for identifying peptides from tandem mass spectra without having to rely on a protein sequence database. Despite the strong potential of de novo sequencing algorithms, their adoption threshold remains quite high. We here present a user-friendly and lightweight graphical user interface called DeNovoGUI for running parallelized versions of the freely available de novo sequencing software PepNovo+, greatly simplifying the use of de novo sequencing in proteomics. Our platform-independent software is freely available under the permissible Apache2 open source license. Source code, binaries, and additional documentation are available at http://denovogui.googlecode.com.
Publisher
American Chemical Society
Journal
Journal of Proteome Research
Copyright
Copyright 2013 American Chemical Society

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