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dc.contributor.authorRobson, Holly
dc.contributor.authorSpecht, Karsten
dc.contributor.authorBeaumont, Helen
dc.contributor.authorParkes, Laura M.
dc.contributor.authorSage, Karen
dc.contributor.authorLambon Ralph, Matthew A.
dc.contributor.authorZahn, Roland
dc.PublishedRobson, Specht K, Beaumont H, Parkes, Sage, Lambon Ralph, Zahn R. Arterial spin labelling shows functional depression of non-lesion tissue in chronic Wernicke's aphasia. Cortex. 2017;92:249-260eng
dc.description.abstractBehavioural impairment post-stroke is a consequence of structural damage and altered functional network dynamics. Hypoperfusion of intact neural tissue is frequently observed in acute stroke, indicating reduced functional capacity of regions outside the lesion. However, cerebral blood flow (CBF) is rarely investigated in chronic stroke. This study investigated CBF in individuals with chronic Wernicke's aphasia (WA) and examined the relationship between lesion, CBF and neuropsychological impairment. Arterial spin labelling CBF imaging and structural MRIs were collected in 12 individuals with chronic WA and 13 age-matched control participants. Joint independent component analysis (jICA) investigated the relationship between structural lesion and hypoperfusion. Partial correlations explored the relationship between lesion, hypoperfusion and language measures. Joint ICA revealed significant differences between the control and WA groups reflecting a large area of structural lesion in the left posterior hemisphere and an associated area of hypoperfusion extending into grey matter surrounding the lesion. Small regions of remote cortical hypoperfusion were observed, ipsilateral and contralateral to the lesion. Significant correlations were observed between the neuropsychological measures (naming, repetition, reading and semantic association) and the jICA component of interest in the WA group. Additional ROI analyses found a relationship between perfusion surrounding the core lesion and the same neuropsychological measures. This study found that core language impairments in chronic WA are associated with a combination of structural lesion and abnormal perfusion in non-lesioned tissue. This indicates that post-stroke impairments are due to a wider disruption of neural function than observable on structural T1w MRI.en_US
dc.rightsAttribution CC BY-NC-NDeng
dc.subjectWernicke's aphasiaeng
dc.subjectLanguage comprehensioneng
dc.subjectCerebral blood floweng
dc.subjectLesion-symptom mappingeng
dc.titleArterial spin labelling shows functional depression of non-lesion tissue in chronic Wernicke's aphasiaeng
dc.typePeer reviewed
dc.typeJournal article
dc.rights.holderCopyright 2016 The Author(s)eng

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