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dc.contributor.authorLien, Sigbjørn
dc.contributor.authorKoop, Ben F
dc.contributor.authorSandve, Simen Rød
dc.contributor.authorMiller, Jason R.
dc.contributor.authorKent, Matthew Peter
dc.contributor.authorNome, Torfinn
dc.contributor.authorHvidsten, Torgeir Rhoden
dc.contributor.authorLeong, Jong
dc.contributor.authorMinkley, David R.
dc.contributor.authorZimin, Aleksey
dc.contributor.authorGrammes, Fabian
dc.contributor.authorGrove, Harald
dc.contributor.authorGjuvsland, Arne Bjørke
dc.contributor.authorWalenz, Brian
dc.contributor.authorHermansen, Russell A.
dc.contributor.authorvon Schalburg, Kristian R.
dc.contributor.authorRondeau, Eric
dc.contributor.authorGenova, Alex Di
dc.contributor.authorAntony Samy, Jeevan Karloss
dc.contributor.authorVik, Jon Olav
dc.contributor.authorVigeland, Magnus Dehli
dc.contributor.authorCaler, Lis
dc.contributor.authorGrimholt, Unni
dc.contributor.authorJentoft, Sissel
dc.contributor.authorVåge, Dag Inge
dc.contributor.authorde Jong, Pieter J.
dc.contributor.authorMoen, Thomas
dc.contributor.authorBaranski, Matthew
dc.contributor.authorPalti, Yniv
dc.contributor.authorSmith, Douglas W.
dc.contributor.authorYorke, James A.
dc.contributor.authorNederbragt, Alexander J.
dc.contributor.authorTooming-Klunderud, Ave
dc.contributor.authorJakobsen, Kjetill Sigurd
dc.contributor.authorJiang, Xuanting
dc.contributor.authorFan, Dingding
dc.contributor.authorHu, Yan
dc.contributor.authorLiberles, David A.
dc.contributor.authorVidal, Rodrigo
dc.contributor.authorIturra, Patricia
dc.contributor.authorJones, Steven J.M.
dc.contributor.authorJonassen, Inge
dc.contributor.authorMaass, Alejandro
dc.contributor.authorOmholt, Stig William
dc.contributor.authorDavidson, William S
dc.PublishedLien S, Koop BF, Sandve SR, Miller JR, Kent MP, Nome T, Hvidsten TRH, Leong J, Minkley, Zimin A, Grammes F, Grove H, Gjuvsland AB, Walenz B, Hermansen RA, von Schalburg KR, Rondeau E, Genova, Antony Samy SJK, Vik JO, Vigeland MD, Caler, Grimholt U, Jentoft S, Våge DI, de Jong PJ, Moen T, Baranski M, Palti Y, Smith DW, Yorke, Nederbragt AJ, Tooming-Klunderud AT, Jakobsen KS, Jiang, Fan, Hu, Liberles DA, Vidal R, Iturra P, Jones SJ, Jonassen I, Maass A, Omholt SW, Davidson WS. The Atlantic salmon genome provides insights into rediploidization. Nature. 2016;533(7602):200-205eng
dc.description.abstractThe whole-genome duplication 80 million years ago of the common ancestor of salmonids (salmonid-specific fourth vertebrate whole-genome duplication, Ss4R) provides unique opportunities to learn about the evolutionary fate of a duplicated vertebrate genome in 70 extant lineages. Here we present a high-quality genome assembly for Atlantic salmon (Salmo salar), and show that large genomic reorganizations, coinciding with bursts of transposon-mediated repeat expansions, were crucial for the post-Ss4R rediploidization process. Comparisons of duplicate gene expression patterns across a wide range of tissues with orthologous genes from a pre-Ss4R outgroup unexpectedly demonstrate far more instances of neofunctionalization than subfunctionalization. Surprisingly, we find that genes that were retained as duplicates after the teleost-specific whole-genome duplication 320 million years ago were not more likely to be retained after the Ss4R, and that the duplicate retention was not influenced to a great extent by the nature of the predicted protein interactions of the gene products. Finally, we demonstrate that the Atlantic salmon assembly can serve as a reference sequence for the study of other salmonids for a range of purposes.en_US
dc.publisherNature Publishing Groupen_US
dc.rightsAttribution CC BYeng
dc.titleThe Atlantic salmon genome provides insights into rediploidizationen_US
dc.typePeer reviewed
dc.typeJournal article
dc.rights.holderCopyright 2016 The Author(s)en_US
dc.relation.projectNorges forskningsråd: 222378
dc.relation.projectNorges forskningsråd: 179569

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