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dc.contributor.authorYndestad, Synnøveen_US
dc.contributor.authorAustreid, Eilinen_US
dc.contributor.authorKnappskog, Stianen_US
dc.contributor.authorChrisanthar, Ranjanen_US
dc.contributor.authorLilleng, Peer Kåreen_US
dc.contributor.authorLønning, Per Eysteinen_US
dc.contributor.authorEikesdal, Hans Petteren_US
dc.description.abstractPurpose: PTEN is an important tumor suppressor in breast cancer. Here, we examined the prognostic and predictive value of PTEN and PTEN pseudogene (PTENP1) gene expression in patients with locally advanced breast cancer given neoadjuvant chemotherapy. Methods: The association between pretreatment PTEN and PTENP1 gene expression, response to neoadjuvant chemotherapy, and recurrence-free and disease-specific survival was assessed in 364 patients with locally advanced breast cancer given doxorubicin, 5-fluorouracil/mitomycin, or epirubicin versus paclitaxel in three phase II prospective studies. Further, protein expression of PTEN or phosphorylated Akt, S6 kinase, and 4EBP1 was assessed in a subgroup of 187 tumors. Results: Neither PTEN nor PTENP1 gene expression level predicted response to any of the chemotherapy regimens tested (n = 317). Among patients without distant metastases (n = 282), a high pretreatment PTEN mRNA level was associated with inferior relapse-free (RFS; p = 0.001) and disease-specific survival (DSS; p = 0.003). Notably, this association was limited to patients harboring TP53 wild-type tumors (RFS; p = 0.003, DSS; p = 0.009). PTEN mRNA correlated significantly with PTENP1 mRNA levels (r s = 0.456, p < 0.0001) and PTEN protein staining (r s = 0.163, p = 0.036). However, no correlation between PTEN, phosphorylated Akt, S6 kinase or 4EBP1 protein staining, and survival was recorded. Similarly, no correlation between PTENP1 gene expression and survival outcome was observed. Conclusion: High intratumoral PTEN gene expression was associated with poor prognosis in patients with locally advanced breast cancers harboring wild-type TP53.en_US
dc.relation.ispartof<a href="" target="blank"> The role of PTEN, PI3K-Akt-mTOR signaling and pseudogene PTENP1 in breast cancer</a>
dc.rightsAttribution CC BYeng
dc.subjectLocally advanced breast cancereng
dc.subjectPredictive factorseng
dc.titleHigh PTEN gene expression is a negative prognostic marker in human primary breast cancers with preserved p53 functionen_US
dc.typePeer reviewed
dc.typeJournal article
dc.rights.holderCopyright The Author(s) 2017
dc.source.journalBreast Cancer Research and Treatment

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