dc.contributor.author | Næsgaard, Patrycja | en_US |
dc.contributor.author | Grundt, Heidi | en_US |
dc.contributor.author | Nordøy, Arne | en_US |
dc.contributor.author | Staines, Harry | en_US |
dc.contributor.author | Nilsen, Dennis W.T. | en_US |
dc.date.accessioned | 2018-06-26T11:44:16Z | |
dc.date.available | 2018-06-26T11:44:16Z | |
dc.date.issued | 2017-07-24 | |
dc.Published | Næsgaard P, Grundt H, Nordøy a, Staines H, Nilsen DW. Vitamin D Uptake in Patients Treated with a High-Dosed Purified Omega-3 Compound in a Randomized Clinical Trial Following an Acute Myocardial Infarction. Frontiers in Cardiovascular Medicine. 2017;4:41 | eng |
dc.identifier.issn | 2297-055X | |
dc.identifier.uri | https://hdl.handle.net/1956/17831 | |
dc.description.abstract | Background: Fish is the natural dietary source of vitamin D. Reports on the influence of purified omega-3 fatty acids on its uptake are scarce. Objectives: We investigated the impact of a purified high-dose omega-3 compound compared to corn oil on 25-hydroxyvitamin D [25(OH)D] levels following an acute myocardial infarction. Methods: 228 patients were randomized 1:1 to receive a daily dose of either 4 g omega-3 (OMACOR®) or an equal dose of corn oil, administered double-blindly for 12 months. Total omega-3 and omega-6 measurements were available in 40 randomly picked patients. Results: There was no significant intergroup difference in 25(OH)D changes at 12 months follow-up (p = 0.12), but there was a minor statistical significant intragroup increase in 25(OH)D in both intervention arms (p < 0.001 for n-3 polyunsaturated fatty acids and p = 0.013 for corn oil, respectively). A positive correlation was noted between 25(OH)D and omega-3 prior to inclusion; r = 0.418, p = 0.007, attenuated at 12 months by purified omega-3 intervention; r = 0.021, p = 0.93. No positive correlation was observed between omega-6 and 25(OH)D. Conclusion: Long-term treatment with a high dose of purified omega-3 as compared to corn oil did not improve serum concentrations of vitamin D. | en_US |
dc.language.iso | eng | eng |
dc.publisher | Frontiers | eng |
dc.rights | Attribution CC BY | eng |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0 | eng |
dc.subject | vitamin D | eng |
dc.subject | omega-3 | eng |
dc.subject | acute myocardial infarction | eng |
dc.subject | 25-hydroxyvitamin D | eng |
dc.subject | omega-6 | eng |
dc.title | Vitamin D Uptake in Patients Treated with a High-Dosed Purified Omega-3 Compound in a Randomized Clinical Trial Following an Acute Myocardial Infarction | en_US |
dc.type | Peer reviewed | |
dc.type | Journal article | |
dc.date.updated | 2018-01-19T10:18:57Z | |
dc.description.version | publishedVersion | en_US |
dc.rights.holder | Copyright 2017 The Author(s) | |
dc.identifier.doi | https://doi.org/10.3389/fcvm.2017.00041 | |
dc.identifier.cristin | 1515664 | |
dc.source.journal | Frontiers in Cardiovascular Medicine | |
dc.subject.nsi | VDP::Medisinske fag: 700::Klinisk medisinske fag: 750::Kardiologi: 771 | |
dc.subject.nsi | VDP::Midical sciences: 700::Clinical medical sciences: 750::Cardiology: 771 | |