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dc.contributor.authorSveinbjørnsson, Baldur
dc.contributor.authorCamilio, Ketil Andre
dc.contributor.authorHaug, Bengt Erik
dc.contributor.authorRekdal, Øystein
dc.date.accessioned2018-07-31T11:19:41Z
dc.date.available2018-07-31T11:19:41Z
dc.date.issued2017
dc.PublishedSveinbjørnsson B, Camilio KA, Haug BE, Rekdal Ø. LTX-315: a first-in-class oncolytic peptide that reprograms the tumor microenvironment. Future Medicinal Chemistry. 2017;9(12):1339-1344eng
dc.identifier.issn1756-8919en_US
dc.identifier.issn1756-8927en_US
dc.identifier.urihttps://hdl.handle.net/1956/17917
dc.description.abstractThe oncolytic peptide LTX-315, which has been de novo designed based on structure–activity relationship studies of host defense peptides, has the ability to kill human cancer cells and induce specific anticancer immune response when injected locally into tumors established in immunocompetent mice. The oncolytic effect of LTX-315 involves perturbation of plasma membrane and the mitochondria with subsequent release of danger-associated molecular pattern molecules, which highlights the ability of LTX-315 to induce complete regression and protective immune responses. Treatment with LTX-315 reprograms the tumor microenvironment by decreasing the local abundance of immunosuppressive cells and by increasing the frequency of effector T cells.en_US
dc.language.isoengeng
dc.publisherFuture Scienceen_US
dc.rightsAttribution CC BY-NC-NDeng
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/eng
dc.subjectCancereng
dc.subjectDAMPeng
dc.subjectimmunotherapyeng
dc.subjectoncolytic peptideeng
dc.titleLTX-315: a first-in-class oncolytic peptide that reprograms the tumor microenvironmenten_US
dc.typePeer reviewed
dc.typeJournal article
dc.date.updated2018-03-13T07:40:07Z
dc.description.versionpublishedVersionen_US
dc.rights.holderCopyright 2017 The Author(s)en_US
dc.identifier.doihttps://doi.org/10.4155/fmc-2017-0088
dc.identifier.cristin1485292
dc.source.journalFuture Medicinal Chemistry


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