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dc.contributor.authorMauland, Karen Klepslanden_US
dc.contributor.authorEng, Øyvin Andre Solbergen_US
dc.contributor.authorYtre-Hauge, Sigmunden_US
dc.contributor.authorTangen, Ingvild Løbergen_US
dc.contributor.authorBerg, Annaen_US
dc.contributor.authorSalvesen, Helgaen_US
dc.contributor.authorSalvesen, Øyvinden_US
dc.contributor.authorKrakstad, Camillaen_US
dc.contributor.authorTrovik, Joneen_US
dc.contributor.authorHøivik, Erling Andreen_US
dc.contributor.authorWerner, Henrica Maria Johannaen_US
dc.contributor.authorMellgren, Gunnaren_US
dc.contributor.authorHaldorsen, Ingfrid S.en_US
dc.PublishedMauland KK, Eng ØAS, Ytre-Hauge S, Tangen IL, Berg A, Salvesen H, Salvesen Ø, Krakstad C, Trovik J, Høivik EA, Werner HMJ, Mellgren G, Haldorsen IS. High visceral fat percentage is associated with poor outcome in endometrial cancer. OncoTarget. 2017;8(62):105184-105195eng
dc.description.abstractDespite evidence of increased endometrial cancer (EC) risk in obese women, the impact of obesity on clinical and histological phenotype is poorly understood. This study explored abdominal fat volumes and fat distribution quantified by computed tomography (CT), in relation to tumor characteristics and outcome. 227 EC patients with preoperative abdominal CT scans were included. Total abdominal fat volume (TAV), subcutaneous abdominal fat volume (SAV) and visceral abdominal fat volume (VAV) were quantified, and visceral fat percentage calculated (VAV%=[VAV/TAV]x100). Waist circumference (WC) and liver density (LD) were measured, and body mass index (BMI) calculated. Data for estrogen, progesterone and androgen receptor (ERα/PR/AR) expression by immunohistochemistry were available for 149 tumors, and global gene expression data for 105 tumors. High BMI, TAV, SAV, VAV and WC, and low LD, were associated with low grade endometrioid tumors and PR and AR positivity (all p≤0.03). High VAV% was associated with high age (p<0.001), aneuploidy (p=0.01) and independently predicted reduced disease-specific survival (HR 1.05, 95% CI 1.00-1.11, p=0.041). Tumors from patients with low VAV% showed enrichment of gene sets related to immune activation and inflammation. In conclusion, high VAV% independently predicts reduced EC survival. Tumors arising in patients with low VAV% show enrichment of immune and inflammation related gene sets, suggesting that the global metabolic setting may be important for tumor immune response.en_US
dc.publisherImpact Journalseng
dc.rightsAttribution CC BYeng
dc.subjectEndometrial cancereng
dc.subjectvisceral fateng
dc.subjecthormone receptor expressioneng
dc.subjecttranscriptional profilingeng
dc.titleHigh visceral fat percentage is associated with poor outcome in endometrial canceren_US
dc.typePeer reviewed
dc.typeJournal article
dc.rights.holderCopyright 2017 The Author(s)

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