dc.contributor.author | Egeland, Grace M. | en_US |
dc.contributor.author | Tell, Grethe S. | en_US |
dc.contributor.author | Næss, Øyvind | en_US |
dc.contributor.author | Igland, Jannicke | en_US |
dc.contributor.author | Klungsøyr, Kari | en_US |
dc.date.accessioned | 2018-08-14T12:46:21Z | |
dc.date.available | 2018-08-14T12:46:21Z | |
dc.date.issued | 2017-08-11 | |
dc.Published | Egeland GM, Tell GST, Næss Ø, Igland J, Klungsøyr K. Association between pregravid physical activity and family history of stroke and risk of stillbirth: Population-based cohort study. BMJ Open. 2017;7:e017034 | eng |
dc.identifier.issn | 2044-6055 | |
dc.identifier.uri | https://hdl.handle.net/1956/18080 | |
dc.description.abstract | Objectives: To evaluate whether family history of disease and pregravid lifestyle and cardiovascular risk factors are associated with subsequent stillbirth delivery. Design: Prepregnancy cohort study. Setting: Cohort Norway regional health surveys (1994–2003) linked to Medical Birth Registry of Norway for deliveries through 2012. Participants: 13 497 singleton births (> 22 weeks gestation) in 8478 women. Main outcome measure: Risk of stillbirth evaluated by Poisson regression. Results: Mean (SD) length of follow-up was 5.5 (3.5) years. In analyses adjusting for baseline age and length of follow-up, ≥3 hours of baseline past-year vigorous physical activity per week (resulting in shortness of breath/sweating) was associated with increased risk of stillbirth compared with <1 hour/week of vigorous activity (incidence rate ratio, IRR 2.46; 95% CI 1.23 to 4.90). In contrast, baseline past-year light physical activity of ≥3 hours per week associated with reduced risk of stillbirth compared with <3 hours of light physical activity per week (IRR 0.53; 95% CI 0.30 to 0.93). A family history of stroke associated with increased risk of stillbirth delivery (IRR 2.53; 95% CI 1.06 to 6.01). Because overweight/obese women may experience shortness of breath and sweating with less physical exertion than normal weight women, a sensitivity analysis was conducted limited to women with a normal BMI (> 18.5 and <25 kg/m2). Vigorous activity of ≥3 hours per week (IRR of 4.50; 95% CI 1.72 to 11.79) and a family history of stroke (IRR of 3.81; 95% CI 1.31 to 11.07) were more strongly related to stillbirth risk among women with a normal BMI than that observed for all women combined. Established risk factors also associated with stillbirth risk. Conclusions: The study identified physical activity and family history of stroke as potential new risk factors for stillbirth delivery. | en_US |
dc.language.iso | eng | eng |
dc.publisher | BMJ | eng |
dc.rights | Attribution CC BY-NC | eng |
dc.rights.uri | http://creativecommons.org/licenses/by-nc/4.0/ | eng |
dc.title | Association between pregravid physical activity and family history of stroke and risk of stillbirth: Population-based cohort study | en_US |
dc.type | Peer reviewed | |
dc.type | Journal article | |
dc.date.updated | 2018-03-06T11:05:39Z | |
dc.description.version | publishedVersion | en_US |
dc.rights.holder | Copyright 2017 The Author(s) | |
dc.identifier.doi | https://doi.org/10.1136/bmjopen-2017-017034 | |
dc.identifier.cristin | 1512623 | |
dc.source.journal | BMJ Open | |