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dc.contributor.authorEgeland, Grace M.en_US
dc.contributor.authorTell, Grethe S.en_US
dc.contributor.authorNæss, Øyvinden_US
dc.contributor.authorIgland, Jannickeen_US
dc.contributor.authorKlungsøyr, Karien_US
dc.date.accessioned2018-08-14T12:46:21Z
dc.date.available2018-08-14T12:46:21Z
dc.date.issued2017-08-11
dc.PublishedEgeland GM, Tell GST, Næss Ø, Igland J, Klungsøyr K. Association between pregravid physical activity and family history of stroke and risk of stillbirth: Population-based cohort study. BMJ Open. 2017;7:e017034eng
dc.identifier.issn2044-6055
dc.identifier.urihttps://hdl.handle.net/1956/18080
dc.description.abstractObjectives: To evaluate whether family history of disease and pregravid lifestyle and cardiovascular risk factors are associated with subsequent stillbirth delivery. Design: Prepregnancy cohort study. Setting: Cohort Norway regional health surveys (1994–2003) linked to Medical Birth Registry of Norway for deliveries through 2012. Participants: 13 497 singleton births (> 22 weeks gestation) in 8478 women. Main outcome measure: Risk of stillbirth evaluated by Poisson regression. Results: Mean (SD) length of follow-up was 5.5 (3.5) years. In analyses adjusting for baseline age and length of follow-up, ≥3 hours of baseline past-year vigorous physical activity per week (resulting in shortness of breath/sweating) was associated with increased risk of stillbirth compared with <1 hour/week of vigorous activity (incidence rate ratio, IRR 2.46; 95% CI 1.23 to 4.90). In contrast, baseline past-year light physical activity of ≥3 hours per week associated with reduced risk of stillbirth compared with <3 hours of light physical activity per week (IRR 0.53; 95% CI 0.30 to 0.93). A family history of stroke associated with increased risk of stillbirth delivery (IRR 2.53; 95% CI 1.06 to 6.01). Because overweight/obese women may experience shortness of breath and sweating with less physical exertion than normal weight women, a sensitivity analysis was conducted limited to women with a normal BMI (> 18.5 and <25 kg/m2). Vigorous activity of ≥3 hours per week (IRR of 4.50; 95% CI 1.72 to 11.79) and a family history of stroke (IRR of 3.81; 95% CI 1.31 to 11.07) were more strongly related to stillbirth risk among women with a normal BMI than that observed for all women combined. Established risk factors also associated with stillbirth risk. Conclusions: The study identified physical activity and family history of stroke as potential new risk factors for stillbirth delivery.en_US
dc.language.isoengeng
dc.publisherBMJeng
dc.rightsAttribution CC BY-NCeng
dc.rights.urihttp://creativecommons.org/licenses/by-nc/4.0/eng
dc.titleAssociation between pregravid physical activity and family history of stroke and risk of stillbirth: Population-based cohort studyen_US
dc.typePeer reviewed
dc.typeJournal article
dc.date.updated2018-03-06T11:05:39Z
dc.description.versionpublishedVersionen_US
dc.rights.holderCopyright 2017 The Author(s)
dc.identifier.doihttps://doi.org/10.1136/bmjopen-2017-017034
dc.identifier.cristin1512623
dc.source.journalBMJ Open


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