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dc.contributor.authorVarhaug, Kristin Nielsenen_US
dc.contributor.authorBarro, Christianen_US
dc.contributor.authorBjørnevik, Kjetil Lauvlanden_US
dc.contributor.authorMyhr, Kjell-Mortenen_US
dc.contributor.authorTorkildsen, Øivinden_US
dc.contributor.authorWergeland, Stigen_US
dc.contributor.authorBindoff, Laurenceen_US
dc.contributor.authorKuhle, Jensen_US
dc.contributor.authorVedeler, Christian A.en_US
dc.PublishedVarhaug K, Barro, Bjørnevik KL, Myhr KM, Torkildsen Ø, Wergeland S, Bindoff L, Kuhle J, Vedeler CA. Neurofilament light chain predicts disease activity in relapsing-remitting MS. Neurology: Neuroimmunology and neuroinflammation. 2018;5:e422eng
dc.description.abstractObjective: To investigate whether serum neurofilament light chain (NF-L) and chitinase 3-like 1 (CHI3L1) predict disease activity in relapsing-remitting MS (RRMS). Methods: A cohort of 85 patients with RRMS were followed for 2 years (6 months without disease-modifying treatment and 18 months with interferon-beta 1a [IFNB-1a]). Expanded Disability Status Scale was scored at baseline and every 6 months thereafter. MRI was performed at baseline and monthly for 9 months and then at months 12 and 24. Serum samples were collected at baseline and months 3, 6, 12, and 24. We analyzed the serum levels of NF-L using a single-molecule array assay and CHI3L1 by ELISA and estimated the association with clinical and MRI disease activity using mixed-effects models. Results: NF-L levels were significantly higher in patients with new T1 gadolinium-enhancing lesions (37.3 pg/mL, interquartile range [IQR] 25.9–52.4) and new T2 lesions (37.3 pg/mL, IQR 25.1–48.5) compared with those without (28.0 pg/mL, IQR 21.9–36.4, β = 1.258, p < 0.001 and 27.7 pg/mL, IQR 21.8–35.1, β = 1.251, p < 0.001, respectively). NF-L levels were associated with the presence of T1 gadolinium-enhanced lesions up to 2 months before (p < 0.001) and 1 month after (p = 0.009) the time of biomarker measurement. NF-L levels fell after initiation of IFNB-1a treatment (p < 0.001). Changes in CHI3L1 were not associated with clinical or MRI disease activity or interferon-beta 1a treatment. Conclusion: Serum NF-L could be a promising biomarker for subclinical MRI activity and treatment response in RRMS. In clinically stable patients, serum NF-L may offer an alternative to MRI monitoring for subclinical disease activity.en_US
dc.publisherWolters Kluwereng
dc.rightsAttribution CC BY-NC-NDeng
dc.titleNeurofilament light chain predicts disease activity in relapsing-remitting MSen_US
dc.typePeer reviewed
dc.typeJournal article
dc.rights.holderCopyright 2017 The Author(s)
dc.source.journalNeurology: Neuroimmunology and neuroinflammation

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