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dc.contributor.authorEngeseth, Merete Salvesonen_US
dc.contributor.authorOlsen, Nina Rydlanden_US
dc.contributor.authorMæland, Siljeen_US
dc.contributor.authorHalvorsen, Thomasen_US
dc.contributor.authorGoode, Adamen_US
dc.contributor.authorRøksund, Ola Drangeen_US
dc.PublishedEngeseth MS, Olsen NR, Mæland S, Halvorsen T, Goode A, Røksund OD. Left Vocal Cord Paralysis After Patent Ductus Arteriosus Ligation: A Systematic Review.. Paediatric Respiratory Reviews. 2018;27:74-85eng
dc.description.abstractContext: Extremely premature (EP) infants are at increased risk of left vocal cord paralysis (LVCP) following surgery for patent ductus arteriosus (PDA). Objective: A Systematical Review was conducted to investigate the incidence and outcomes of LVCP after PDA ligation in EP born infants. Data sources: Searches were performed in Cochrane, Medline, Embase, Cinahl and PsycInfo. Study selection: Studies describing EP infants undergoing PDA surgery and reporting incidence of LVCP were included. Data extraction and synthesis: Study details, demographics, incidence of LVCP, diagnostic method and reported outcomes were extracted. DerSimonian and Laird random effect models with inverse variance weighting were used for all analyses. Study appraisal: The Newcastle-Ottawa scale for observational studies was used for quality assessment. Results: 21 publications including 2067 infants were studied. The overall pooled summary estimate of LVCP incidence was 9.0% (95% CI 5.0, 15.0). However, the pooled incidence increased to 32% when only infants examined with laryngoscopy were included. The overall risk ratio for negative outcomes was higher in the LVCP group (2.20, 95% CI 1.69, 2.88, p = 0.01) compared to the non-LVCP-group. Conclusions: Reported incidence of LVCP varies widely. This may be explained by differences in study designs and lack of routine vocal cords postoperative assessment. LVCP is associated with negative outcomes in EP infants. The understanding of long-term outcomes is scarce. Routine laryngoscopy may be necessary to identify all cases of LVCP, and to provide correct handling for infants with LVCP.en_US
dc.rightsAttribution CC BY-NC-NDeng
dc.subjectextremely low birth weighteng
dc.subjectextremely prematureeng
dc.subjectRecurrent laryngeal nerveeng
dc.titleLeft Vocal Cord Paralysis After Patent Ductus Arteriosus Ligation: A Systematic Review.en_US
dc.typePeer reviewed
dc.typeJournal article
dc.rights.holderCopyright 2018 The Author(s)
dc.source.journalPaediatric Respiratory Reviews

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