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dc.contributor.authorSveen, Lene Rydal
dc.contributor.authorTimmerhaus, Gerrit
dc.contributor.authorKrasnov, Aleksei
dc.contributor.authorTakle, Harald
dc.contributor.authorStefansson, Sigurd Olav
dc.contributor.authorHandeland, Sigurd O
dc.contributor.authorYtteborg, Elisabeth
dc.PublishedSveen L, Timmerhaus GF, Krasnov A, Takle H, Stefansson SO, Handeland SO, Ytteborg E. High fish density delays wound healing in Atlantic salmon (Salmo salar). Scientific Reports. 2018;8:16907eng
dc.description.abstractIn this study, we look closer at how high fish densities influence wound repair mechanisms in post-smolt Atlantic salmon. The fish were wounded with a 5 mm skin punch biopsy needle and stocked at two different densities, a high fish density (100 kg/m3) treatment and a low fish density treatment (20 kg/m3) serving as the control. The healing wounds were followed for 57 days with samples taken 1, 3, 7, 14, 36, 43 and 57 days post wounding. The transcriptomic analysis suggests that high fish density enhance inflammation and represses cell proliferation, tissue secretion and collagen synthesis in the healing wounds. The histological analysis further showed delayed epidermal and dermal repair in the high fish density treatment compared to control. The overall wound contraction was also altered by the treatment. In conclusion, high fish density enhances immune responses and delay tissue repair, which ultimately results in delayed wound healing.en_US
dc.publisherNature Publishingen_US
dc.relation.ispartof<a href="" target="blank">Aquaculture relevant stressors and their impacts on skin and wound healing in post-smolt Atlantic salmon (Salmo salar L.)</a>en_US
dc.rightsAttribution CC BYeng
dc.titleHigh fish density delays wound healing in Atlantic salmon (Salmo salar)en_US
dc.typePeer reviewed
dc.typeJournal article
dc.rights.holderCopyright the Author(s) 2018en_US
dc.source.journalScientific Reports
dc.relation.projectNorges forskningsråd: 237856

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