Browsing Master theses by Title
Now showing items 19-33 of 33
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LPS quantification of oral samples from the RHINESSA study population
(Master thesis, 2023-06-01)The human immune system defends the body against threats through a complex network of organs, cells, and proteins. It has two subsystems: the innate immune system provides immediate defense, while the adaptive immune system ... -
Making in vivo models viable again: Synthetic lethality between DNA repair factors Xlf and Paxx is rescued by inactivation of Trp53
(Master thesis, 2019-06-28)Non-Homologous End-Joining (NHEJ) is the major DNA repair pathway that senses, processes and ligates DNA double strand breaks (DSBs) in higher eukaryotes, functionally throughout the cell cycle. The NHEJ involves four core ... -
Matrix Stiffness-dependent Regulation of Integrin α11β1 Expression
(Master thesis, 2023-06-01)Stiffness regulation within the tumour microenvironment plays a pivotal role in tumorigenesis. In this context, integrin α11β1 is a collagen receptor expressed on cancer-associated fibroblasts (CAFs) involved in matrix ... -
A novel 3D PDAC model system developed with the use of decellularized matrix scaffolds
(Master thesis, 2019-06-28) -
Novel aspects of carboxyl ester lipase (CEL). Investigations on transcriptional regulation and tissue expression
(Master thesis, 2024-06-03)Carboxyl ester lipase (CEL) is a digestive enzyme that breaks down dietary fats in the duodenum, and it is mainly expressed by the pancreas and lactating mammary glands. A pathogenic variant of the CEL gene, named CEL-HYB1, ... -
Pharmacological targeting of the Treg/Th17 axis using in vitro cell cultures derived from patients with autoimmune Addison's disease
(Master thesis, 2022-06-01)Autoimmune Addison’s disease (AAD) is a rare endocrine disorder characterized by an immune-mediated attack towards the cells of the adrenal cortex. The major self-antigen, targeted by autoantibodies and self-reactive T ... -
Role of mechanotransduction in pancreatic endocrine cell fate acquisition in SC-islets
(Master thesis, 2024-06-03) -
The role of pyruvate dehydrogenase kinases (PDKs) in rewiring of cell metabolism under energy stress
(Master thesis, 2019-06-28)Irregularities in cellular energy metabolism have been linked to many human diseases, including metabolic disorders, mitochondrial diseases, cancer, and neurodegeneration. In order to survive and function properly, an ... -
Structure-based design of pantothenate kinase inhibitors as lead structures for new antibiotics
(Master thesis, 2020-06-23) -
The CEL VNTR in pancreatic disease: Effects of cysteine residues in pathogenic carboxyl ester lipase variants
(Master thesis, 2023-06-01)Carboxyl ester lipase (CEL) is a digestive enzyme mainly expressed in the acinar cells of the pancreas. CEL hydrolyses dietary fat, cholesteryl esters and fat-soluble vitamins. The protein is structurally divided into two ... -
The Role of apoptosis in suicide gene therapy of glioblastoma
(Master thesis, 2021-12-01) -
The Search for Antibiotic Leads: Targeting Pantothenate Kinase in Pseudomonas aeruginosa
(Master thesis, 2021-06-01) -
TOWARDS DEFINING THE ENDOMEMBRANE COMPARTMENTS OPERATING IN CELLULAR EXIT OF CORONVIRUSES
(Master thesis, 2021-06-01) -
Using iPSC-derived cortical organoids to study disease mechanisms of POLG-disease and explore new therapeutic strategies
(Master thesis, 2023-07-03)POLG-related diseases are a set of severe mitochondrial myopathies caused by a mutation in the POLG gene. The POLG gene encodes for the catalytic subunit of the mitochondrial DNA (mtDNA) polymerase gamma (Pol-γ). Pol-γ is ...