Browsing Master theses by Title
Now showing items 9-28 of 33
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Effect of miR-582-5p modulated cancer-associated fibroblasts on vulvar cancer cells
(Master thesis, 2022-06-01) -
Exploring the IBS Brain: Resting State Functional Connectivity and Machine Learning
(Master thesis, 2019-06-28) -
Expression, Purification, and Small Molecule Binding to Cysteine Sulfinic Acid Decarboxylase
(Master thesis, 2023-06-01)Cysteine Sulfinic acid decarboxylase (CSAD) is a PLP-dependent enzyme involved in the biosynthesis of taurine. It converts cysteine sulfinic acid (CSA) into hypotaurine. Hypotaurine is later oxidized into taurine, one of ... -
High-dimensional Characterisation of rare cerebrospinal fluid cells in relapsing remitting multiple sclerosis patients
(Master thesis, 2023-06-01)Multiple Sclerosis (MS) is a chronic inflammatory and neurodegenerative disease of the central nervous system (CNS) and is the leading cause of neurological disability in young adults in North America and Europe, affecting ... -
Image Registration for Automated Alignment and Ordering of Non-neoplastic Kidney Biopsy Sections
(Master thesis, 2024-06-03)The kidney, a vital organ responsible for waste excretion and hormone regulation, is frequently afflicted by non-neoplastic diseases affecting components like glomeruli and tubules. Chronic kidney disease (CKD), often ... -
Improvement of a 3D model system for the evaluation and treatment of pancreatic ductal adenocarcinoma
(Master thesis, 2021-06-01) -
In vitro study of a selective PI3K inhibitor on brain metastases
(Master thesis, 2020-06-17) -
Interplay of the proteotoxic CEL-MODY protein and oncogenic KRAS in pancreatic cancer development
(Master thesis, 2024-06-03)Challenges in diagnosing and treating pancreatic cancer make it the fourth-leading cause of cancer-related deaths. Survival rates remain dismally low, and the molecular mechanisms driving this malignancy are still inadequately ... -
Investigation of the apoptotic pathway in glioblastoma in the context of suicide gene therapy
(Master thesis, 2023-06-01)Glioblastoma is a highly malignant, aggressive and most common primary brain tumor in adults. Tremendous research efforts have been conducted in the field of GBM treatment discovery and succcess has only been achieved at ... -
Investigation of the Role of BCR/ABL1 in Neutrophil Extracellular Trap (NET) Formation in Chronic Myeloid Leukemia (CML)
(Master thesis, 2022-06-01)Neutrophil extracellular traps (NETs) represent a rather newly discovered antimicrobial mechanism first described by Brinkmann and co-workers in 2004. NETs are extracellular structures composed of decondensed chromatin ... -
LPS quantification of oral samples from the RHINESSA study population
(Master thesis, 2023-06-01)The human immune system defends the body against threats through a complex network of organs, cells, and proteins. It has two subsystems: the innate immune system provides immediate defense, while the adaptive immune system ... -
Making in vivo models viable again: Synthetic lethality between DNA repair factors Xlf and Paxx is rescued by inactivation of Trp53
(Master thesis, 2019-06-28)Non-Homologous End-Joining (NHEJ) is the major DNA repair pathway that senses, processes and ligates DNA double strand breaks (DSBs) in higher eukaryotes, functionally throughout the cell cycle. The NHEJ involves four core ... -
Matrix Stiffness-dependent Regulation of Integrin α11β1 Expression
(Master thesis, 2023-06-01)Stiffness regulation within the tumour microenvironment plays a pivotal role in tumorigenesis. In this context, integrin α11β1 is a collagen receptor expressed on cancer-associated fibroblasts (CAFs) involved in matrix ... -
A novel 3D PDAC model system developed with the use of decellularized matrix scaffolds
(Master thesis, 2019-06-28) -
Novel aspects of carboxyl ester lipase (CEL). Investigations on transcriptional regulation and tissue expression
(Master thesis, 2024-06-03)Carboxyl ester lipase (CEL) is a digestive enzyme that breaks down dietary fats in the duodenum, and it is mainly expressed by the pancreas and lactating mammary glands. A pathogenic variant of the CEL gene, named CEL-HYB1, ... -
Pharmacological targeting of the Treg/Th17 axis using in vitro cell cultures derived from patients with autoimmune Addison's disease
(Master thesis, 2022-06-01)Autoimmune Addison’s disease (AAD) is a rare endocrine disorder characterized by an immune-mediated attack towards the cells of the adrenal cortex. The major self-antigen, targeted by autoantibodies and self-reactive T ... -
Role of mechanotransduction in pancreatic endocrine cell fate acquisition in SC-islets
(Master thesis, 2024-06-03) -
The role of pyruvate dehydrogenase kinases (PDKs) in rewiring of cell metabolism under energy stress
(Master thesis, 2019-06-28)Irregularities in cellular energy metabolism have been linked to many human diseases, including metabolic disorders, mitochondrial diseases, cancer, and neurodegeneration. In order to survive and function properly, an ... -
Structure-based design of pantothenate kinase inhibitors as lead structures for new antibiotics
(Master thesis, 2020-06-23)