Browsing Master theses by Title
Now showing items 9-20 of 20
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Functional consequences of modulated expression of SLC25A51 on cellular NAD metabolism
(Master thesis, 2022-06-01)Nicotinamide adenine dinucleotide is a small molecule involved in the regulation of signaling pathways and energy transduction. In the compartmentalized human cell, mitochondria are considered to constitute the major pool ... -
Improvement of a 3D model system for the evaluation and treatment of pancreatic ductal adenocarcinoma
(Master thesis, 2021-06-01) -
In vitro study of a selective PI3K inhibitor on brain metastases
(Master thesis, 2020-06-17) -
Investigation of the Role of BCR/ABL1 in Neutrophil Extracellular Trap (NET) Formation in Chronic Myeloid Leukemia (CML)
(Master thesis, 2022-06-01)Neutrophil extracellular traps (NETs) represent a rather newly discovered antimicrobial mechanism first described by Brinkmann and co-workers in 2004. NETs are extracellular structures composed of decondensed chromatin ... -
Making in vivo models viable again: Synthetic lethality between DNA repair factors Xlf and Paxx is rescued by inactivation of Trp53
(Master thesis, 2019-06-28)Non-Homologous End-Joining (NHEJ) is the major DNA repair pathway that senses, processes and ligates DNA double strand breaks (DSBs) in higher eukaryotes, functionally throughout the cell cycle. The NHEJ involves four core ... -
A novel 3D PDAC model system developed with the use of decellularized matrix scaffolds
(Master thesis, 2019-06-28) -
Pharmacological targeting of the Treg/Th17 axis using in vitro cell cultures derived from patients with autoimmune Addison's disease
(Master thesis, 2022-06-01)Autoimmune Addison’s disease (AAD) is a rare endocrine disorder characterized by an immune-mediated attack towards the cells of the adrenal cortex. The major self-antigen, targeted by autoantibodies and self-reactive T ... -
The role of pyruvate dehydrogenase kinases (PDKs) in rewiring of cell metabolism under energy stress
(Master thesis, 2019-06-28)Irregularities in cellular energy metabolism have been linked to many human diseases, including metabolic disorders, mitochondrial diseases, cancer, and neurodegeneration. In order to survive and function properly, an ... -
Structure-based design of pantothenate kinase inhibitors as lead structures for new antibiotics
(Master thesis, 2020-06-23) -
The Role of apoptosis in suicide gene therapy of glioblastoma
(Master thesis, 2021-12-01) -
The Search for Antibiotic Leads: Targeting Pantothenate Kinase in Pseudomonas aeruginosa
(Master thesis, 2021-06-01) -
TOWARDS DEFINING THE ENDOMEMBRANE COMPARTMENTS OPERATING IN CELLULAR EXIT OF CORONVIRUSES
(Master thesis, 2021-06-01)