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dc.contributor.authorde Jong, Simoneen_US
dc.contributor.authorDiniz, Mateus Jose Abdallaen_US
dc.contributor.authorSaloma, Andiaraen_US
dc.contributor.authorGadelha, Aryen_US
dc.contributor.authorSantoro, Marcos L.en_US
dc.contributor.authorOta, Vanessa K.en_US
dc.contributor.authorNoto, Cristianoen_US
dc.contributor.authorMorken, Gunnaren_US
dc.contributor.authorAndreassen, Ole Andreasen_US
dc.contributor.authorMelle, Ingriden_US
dc.contributor.authorDjurovic, Srdjanen_US
dc.contributor.authorCurtis, Charlesen_US
dc.contributor.authorNewhouse, Stephen J.en_US
dc.contributor.authorPatel, Hamelen_US
dc.contributor.authorHall, Lynsey S.en_US
dc.contributor.authorO`Reilly, Paul F.en_US
dc.contributor.authorBelangero, Sintia I.en_US
dc.contributor.authorBressan, Rodrigo A.en_US
dc.contributor.authorBreen, Geromeen_US
dc.Publishedde Jong S, Diniz, Saloma, Gadelha, Santoro, Ota, Noto, Morken G, Andreassen OA, Melle I, Djurovic S, Curtis C, Newhouse, Patel, Hall, O`Reilly, Belangero, Bressan, Breen G. Applying polygenic risk scoring for psychiatric disorders to a large family with bipolar disorder and major depressive disorder. Communications Biology. 2018;1:163eng
dc.description.abstractPsychiatric disorders are thought to have a complex genetic pathology consisting of interplay of common and rare variation. Traditionally, pedigrees are used to shed light on the latter only, while here we discuss the application of polygenic risk scores to also highlight patterns of common genetic risk. We analyze polygenic risk scores for psychiatric disorders in a large pedigree (n ~ 260) in which 30% of family members suffer from major depressive disorder or bipolar disorder. Studying patterns of assortative mating and anticipation, it appears increased polygenic risk is contributed by affected individuals who married into the family, resulting in an increasing genetic risk over generations. This may explain the observation of anticipation in mood disorders, whereby onset is earlier and the severity increases over the generations of a family. Joint analyses of rare and common variation may be a powerful way to understand the familial genetics of psychiatric disorders.en_US
dc.publisherNature Researcheng
dc.rightsAttribution CC BYeng
dc.titleApplying polygenic risk scoring for psychiatric disorders to a large family with bipolar disorder and major depressive disorderen_US
dc.typePeer reviewed
dc.typeJournal article
dc.rights.holderCopyright 2018 The Authors
dc.source.journalCommunications Biology

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