dc.contributor.author | Tvedt, Tor Henrik Anderson | en_US |
dc.contributor.author | Melve, Guro Kristin | en_US |
dc.contributor.author | Tsykunova, Galina | en_US |
dc.contributor.author | Ahmed, Aymen B | en_US |
dc.contributor.author | Brenner, Annette | en_US |
dc.contributor.author | Bruserud, Øystein | en_US |
dc.date.accessioned | 2019-05-29T10:52:17Z | |
dc.date.available | 2019-05-29T10:52:17Z | |
dc.date.issued | 2018-09-22 | |
dc.Published | Tvedt THA, Melve GK, Tsykunova G, Ahmed AB, Brenner AK, Bruserud Ø. Immunological heterogeneity of healthy peripheral blood stem cell donors - Effects of granulocyte colony-stimulating factor on inflammatory responses. International Journal of Molecular Sciences. 2018;19(10):2886 | eng |
dc.identifier.issn | 1422-0067 | |
dc.identifier.uri | https://hdl.handle.net/1956/19805 | |
dc.description.abstract | Interleukin-6 (IL-6) contributes to the development of immune-mediated complications after allogeneic stem cell transplantation. However, systemic IL-6 levels also increase during granulocyte colony-stimulating factor (G-CSF) mobilization of hematopoietic stem cells in healthy donors, but it is not known whether this mobilization alters systemic levels of other IL-6 family cytokines/receptors and whether such effects differ between donors. We examined how G-CSF administration influenced C-reactive protein (CRP) levels (85 donors) and serum levels of IL-6 family cytokines/receptors (20 donors). G-CSF increased CRP levels especially in elderly donors with high pretherapy levels, but these preharvesting levels did not influence clinical outcomes (nonrelapse mortality, graft versus host disease). The increased IL-6 levels during G-CSF therapy normalized within 24 h after treatment. G-CSF administration did not alter serum levels of other IL-6-familly mediators. Oncostatin M, but not IL-6, showed a significant correlation with CRP levels during G-CSF therapy. Clustering analysis of mediator levels during G-CSF administration identified two donor subsets mainly characterized by high oncostatin M and IL-6 levels, respectively. Finally, G-CSF could increase IL-6 release by in vitro cultured monocytes, fibroblasts, and mesenchymal stem cells. In summary, G-CSF seems to induce an acute phase reaction with increased systemic IL-6 levels in healthy stem cell donors. | en_US |
dc.language.iso | eng | eng |
dc.publisher | MDPI | eng |
dc.rights | Attribution CC BY | eng |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0 | eng |
dc.subject | toll-like receptors | eng |
dc.subject | Interleukin-6 | eng |
dc.subject | C-reactive protein | eng |
dc.subject | acute-phase reaction | eng |
dc.subject | graft versus host disease | eng |
dc.subject | tissue and organ procurement | eng |
dc.title | Immunological heterogeneity of healthy peripheral blood stem cell donors - Effects of granulocyte colony-stimulating factor on inflammatory responses | en_US |
dc.type | Peer reviewed | |
dc.type | Journal article | |
dc.date.updated | 2019-01-24T10:37:53Z | |
dc.description.version | publishedVersion | en_US |
dc.rights.holder | Copyright 2018 The Author(s) | |
dc.identifier.doi | https://doi.org/10.3390/ijms19102886 | |
dc.identifier.cristin | 1612792 | |
dc.source.journal | International Journal of Molecular Sciences | |