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dc.contributor.authorMjelle, Anders Batmanen_US
dc.contributor.authorMulabecirovic, Anesaen_US
dc.contributor.authorHavre, Roald Fleslanden_US
dc.contributor.authorRosendahl, Karenen_US
dc.contributor.authorJuliusson, Petur Benedikten_US
dc.contributor.authorOlafsdottir, Edda Joninaen_US
dc.contributor.authorGilja, Odd Helgeen_US
dc.contributor.authorVesterhus, Metteen_US
dc.PublishedMjelle AB, Mulabecirovic A, Havre R, Rosendahl K, Juliusson P, Olafsdottir EJ, Gilja OH, Vesterhus M. Normal Liver Stiffness Values in Children - A Comparison of Three Different Elastography Methods. Journal of Pediatric Gastroenterology and Nutrition - JPGN. 2019;68:706–712eng
dc.description.abstractObjectives: Noninvasive tests for the evaluation of liver fibrosis are particularly helpful in children to avoid general anesthesia and potential complications of invasive tests. We aimed to establish reference values for 2 different elastography methods in a head-to-head comparison for children and adolescents 4 to 17 years, using transient elastography as common reference in a subset. Methods: A total of 243 healthy participants aged 4 to 17 years were examined by a single observer with a full liver B-mode scan before elastography, following a minimum of 3 hours fasting. Liver stiffness measurements (LSMs) using 2-dimensional shear wave elastography (2D-SWE, GE Logiq E9) and point shear wave elastography (pSWE, Samsung RS80A with Prestige) were performed in all participants, and compared to transient elastography (TE, FibroScan) in a subset (n = 87). Interobserver agreement was evaluated in 50 children aged 4 to 17 years. Results: Valid measurements were obtained in 242 of 243 (99.6%) subjects for 2D-SWE, 238 of 243 (97.9%) for pSWE, and in 83 of 87 (95.4%) for TE. Median liver stiffness overall was 3.3 (interquartile range [IQR] 2.7–4.3), 4.1 (IQR 3.6–4.7), and 4.1 kPa (IQR 3.5–4.6) for 2D-SWE, pSWE, and TE, respectively. Intraclass correlation coefficients between observers were 0.84 and 0.83 for 2D-SWE and pSWE, respectively. LSM values were significantly lower for 2D-SWE compared to pSWE and TE, and increased with advancing age. Higher LSM values in males were observed in adolescents. Conclusions: All methods showed excellent feasibility. 2D-SWE showed significantly lower LSM values than pSWE and TE, and lower failure rate compared to TE. Our results further indicate an age and sex effect on LSM values.en_US
dc.publisherWolters Kluwereng
dc.rightsAttribution CC BY-NC-NDeng
dc.subjectliver fibrosiseng
dc.subjectshear wave elastographyeng
dc.subjecttransient elastographyeng
dc.titleNormal Liver Stiffness Values in Children - A Comparison of Three Different Elastography Methodsen_US
dc.typePeer reviewed
dc.typeJournal article
dc.rights.holderCopyright 2019 The Author(s)
dc.source.journalJournal of Pediatric Gastroenterology and Nutrition - JPGN

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