dc.contributor.author | Mjelle, Anders Batman | en_US |
dc.contributor.author | Mulabecirovic, Anesa | en_US |
dc.contributor.author | Havre, Roald Flesland | en_US |
dc.contributor.author | Rosendahl, Karen | en_US |
dc.contributor.author | Juliusson, Petur Benedikt | en_US |
dc.contributor.author | Olafsdottir, Edda Jonina | en_US |
dc.contributor.author | Gilja, Odd Helge | en_US |
dc.contributor.author | Vesterhus, Mette | en_US |
dc.date.accessioned | 2019-06-05T08:19:51Z | |
dc.date.available | 2019-06-05T08:19:51Z | |
dc.date.issued | 2019-05 | |
dc.Published | Mjelle AB, Mulabecirovic A, Havre R, Rosendahl K, Juliusson P, Olafsdottir EJ, Gilja OH, Vesterhus M. Normal Liver Stiffness Values in Children - A Comparison of Three Different Elastography Methods. Journal of Pediatric Gastroenterology and Nutrition - JPGN. 2019;68:706–712 | eng |
dc.identifier.issn | 0277-2116 | |
dc.identifier.issn | 1536-4801 | |
dc.identifier.uri | https://hdl.handle.net/1956/19864 | |
dc.description.abstract | Objectives: Noninvasive tests for the evaluation of liver fibrosis are particularly helpful in children to avoid general anesthesia and potential complications of invasive tests. We aimed to establish reference values for 2 different elastography methods in a head-to-head comparison for children and adolescents 4 to 17 years, using transient elastography as common reference in a subset. Methods: A total of 243 healthy participants aged 4 to 17 years were examined by a single observer with a full liver B-mode scan before elastography, following a minimum of 3 hours fasting. Liver stiffness measurements (LSMs) using 2-dimensional shear wave elastography (2D-SWE, GE Logiq E9) and point shear wave elastography (pSWE, Samsung RS80A with Prestige) were performed in all participants, and compared to transient elastography (TE, FibroScan) in a subset (n = 87). Interobserver agreement was evaluated in 50 children aged 4 to 17 years. Results: Valid measurements were obtained in 242 of 243 (99.6%) subjects for 2D-SWE, 238 of 243 (97.9%) for pSWE, and in 83 of 87 (95.4%) for TE. Median liver stiffness overall was 3.3 (interquartile range [IQR] 2.7–4.3), 4.1 (IQR 3.6–4.7), and 4.1 kPa (IQR 3.5–4.6) for 2D-SWE, pSWE, and TE, respectively. Intraclass correlation coefficients between observers were 0.84 and 0.83 for 2D-SWE and pSWE, respectively. LSM values were significantly lower for 2D-SWE compared to pSWE and TE, and increased with advancing age. Higher LSM values in males were observed in adolescents. Conclusions: All methods showed excellent feasibility. 2D-SWE showed significantly lower LSM values than pSWE and TE, and lower failure rate compared to TE. Our results further indicate an age and sex effect on LSM values. | en_US |
dc.language.iso | eng | eng |
dc.publisher | Wolters Kluwer | eng |
dc.relation.uri | https://journals.lww.com/jpgn/Abstract/publishahead/Normal_Liver_Stiffness_Values_in_Children___A.96518.aspx#pdf-link | |
dc.rights | Attribution CC BY-NC-ND | eng |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | eng |
dc.subject | liver fibrosis | eng |
dc.subject | pediatric | eng |
dc.subject | shear wave elastography | eng |
dc.subject | transient elastography | eng |
dc.subject | ultrasound | eng |
dc.title | Normal Liver Stiffness Values in Children - A Comparison of Three Different Elastography Methods | en_US |
dc.type | Peer reviewed | |
dc.type | Journal article | |
dc.date.updated | 2019-04-03T12:11:14Z | |
dc.description.version | publishedVersion | en_US |
dc.rights.holder | Copyright 2019 The Author(s) | |
dc.identifier.doi | https://doi.org/10.1097/mpg.0000000000002320 | |
dc.identifier.cristin | 1690008 | |
dc.source.journal | Journal of Pediatric Gastroenterology and Nutrition - JPGN | |