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dc.contributor.authorO'Mara, Tracy A.en_US
dc.contributor.authorGlubb, Dylan M.en_US
dc.contributor.authorAmant, Frédéricen_US
dc.contributor.authorAnnibali, Danielaen_US
dc.contributor.authorAshton, Katieen_US
dc.contributor.authorAttia, Johnen_US
dc.contributor.authorAuer, Paul L.en_US
dc.contributor.authorBeckmann, Matthias W.en_US
dc.contributor.authorBlack, Amandaen_US
dc.contributor.authorBolla, Manjeet K.en_US
dc.contributor.authorBrauch, Hiltruden_US
dc.contributor.authorBrenner, Hermannen_US
dc.contributor.authorBrinton, Louiseen_US
dc.contributor.authorBuchanan, Daniel D.en_US
dc.contributor.authorBurwinkel, Barbaraen_US
dc.contributor.authorChang-Claude, Jennyen_US
dc.contributor.authorChanock, Stephen J.en_US
dc.contributor.authorChen, Chuen_US
dc.contributor.authorChen, Maxine M.en_US
dc.contributor.authorCheng, Timothy H.T.en_US
dc.contributor.authorClarke, Christine L.en_US
dc.contributor.authorClendenning, Marken_US
dc.contributor.authorCook, Linda S.en_US
dc.contributor.authorCouch, Fergus J.en_US
dc.contributor.authorCox, Angelaen_US
dc.contributor.authorCrous-Bous, Martaen_US
dc.contributor.authorCzene, Kamilaen_US
dc.contributor.authorDay, Felixen_US
dc.contributor.authorDennis, Joeen_US
dc.contributor.authorDepreeuw, Jeroenen_US
dc.contributor.authorDoherty, Jennifer Anneen_US
dc.contributor.authorDörk, Thiloen_US
dc.contributor.authorDowdy, Sean C.en_US
dc.contributor.authorDürst, Matthiasen_US
dc.contributor.authorEkici, Arif B.en_US
dc.contributor.authorFasching, Peter A.en_US
dc.contributor.authorFridley, Brooke L.en_US
dc.contributor.authorFriedenreich, Christine M.en_US
dc.contributor.authorFritschi, Linen_US
dc.contributor.authorFung, Jennyen_US
dc.contributor.authorGarcía-Closas, Montserraten_US
dc.contributor.authorGaudet, Mia M.en_US
dc.contributor.authorGiles, Graham G.en_US
dc.contributor.authorGoode, Ellen L.en_US
dc.contributor.authorGorman, Maggieen_US
dc.contributor.authorHaiman, Christopher A.en_US
dc.contributor.authorHall, Peren_US
dc.contributor.authorHankison, Susan E.en_US
dc.contributor.authorHealey, Catherine S.en_US
dc.contributor.authorHein, Alexanderen_US
dc.contributor.authorHillemanns, Peteren_US
dc.contributor.authorHodgson, Shirleyen_US
dc.contributor.authorHøivik, Erling Andreen_US
dc.contributor.authorHolliday, Elizabeth G.en_US
dc.contributor.authorHopper, John L.en_US
dc.contributor.authorHunter, David J.en_US
dc.contributor.authorJones, Angelaen_US
dc.contributor.authorKrakstad, Camillaen_US
dc.contributor.authorKristensen, Vessela N.en_US
dc.contributor.authorLambrechts, Dietheren_US
dc.contributor.authorMarchand, Loic Leen_US
dc.contributor.authorLiang, Xiaolinen_US
dc.contributor.authorLindblom, Annikaen_US
dc.contributor.authorLissowska, Jolantaen_US
dc.contributor.authorLong, Jirongen_US
dc.contributor.authorLu, Lingengen_US
dc.contributor.authorMagliocco, Anthony M.en_US
dc.contributor.authorMartin, Lynnen_US
dc.contributor.authorMcEvoy, Marken_US
dc.contributor.authorMeindl, Alfonsen_US
dc.contributor.authorMichailidou, Kyriakien_US
dc.contributor.authorMilne, Roger L.en_US
dc.contributor.authorMints, Miriamen_US
dc.contributor.authorMontgomery, Grant W.en_US
dc.contributor.authorNassir, Ramien_US
dc.contributor.authorOlsson, Håkanen_US
dc.contributor.authorOrlow, Ireneen_US
dc.contributor.authorOtton, Geoffreyen_US
dc.contributor.authorPalles, Claireen_US
dc.contributor.authorPerry, John R.B.en_US
dc.contributor.authorPeto, Julianen_US
dc.contributor.authorPooler, Loreallen_US
dc.contributor.authorPrescott, Jenniferen_US
dc.contributor.authorProietto, Tonyen_US
dc.contributor.authorRebbeck, Timothy R.en_US
dc.contributor.authorRisch, Harvey A.en_US
dc.contributor.authorRogers, Peter A.W.en_US
dc.contributor.authorRübner, Matthiasen_US
dc.contributor.authorRunnebaum, Ingoen_US
dc.contributor.authorSacerdote, Carlottaen_US
dc.contributor.authorSarto, Gloria E.en_US
dc.contributor.authorSchumacher, Fredricken_US
dc.contributor.authorScott, Rodney J.en_US
dc.contributor.authorSetiawan, V. Wendyen_US
dc.contributor.authorShah, Mitulen_US
dc.contributor.authorSheng, Xinen_US
dc.contributor.authorShu, Xiao-Ouen_US
dc.contributor.authorSouthey, Melissa C.en_US
dc.contributor.authorSwerdlow, Anthony J.en_US
dc.contributor.authorTham, Emmaen_US
dc.contributor.authorTrovik, Joneen_US
dc.contributor.authorTurman, Constanceen_US
dc.contributor.authorTyrer, Jonathan P.en_US
dc.contributor.authorVachon, Celineen_US
dc.contributor.authorVanDen Berg, Daviden_US
dc.contributor.authorVanderstichele, Adriaanen_US
dc.contributor.authorWang, Zhaomingen_US
dc.contributor.authorWebb, Penelope M.en_US
dc.contributor.authorWentzensen, Nicolasen_US
dc.contributor.authorWerner, Henrica Maria Johannaen_US
dc.contributor.authorWinham, Stacey J.en_US
dc.contributor.authorWolk, Alicjaen_US
dc.contributor.authorXia, Lucyen_US
dc.contributor.authorXiang, Yong-Bingen_US
dc.contributor.authorYang, Hannah P.en_US
dc.contributor.authorYu, Herberten_US
dc.contributor.authorZheng, Weien_US
dc.contributor.authorPharoah, Paul D.P.en_US
dc.contributor.authorDunning, Alison M.en_US
dc.contributor.authorKraft, Peteren_US
dc.contributor.authorDe Vivo, Immaculataen_US
dc.contributor.authorTomlinson, Ianen_US
dc.contributor.authorEaston, Douglas F.en_US
dc.contributor.authorSpurdle, Amanda B.en_US
dc.contributor.authorThompson, Deborah J.en_US
dc.date.accessioned2019-06-07T09:22:04Z
dc.date.available2019-06-07T09:22:04Z
dc.date.issued2018-08-09
dc.PublishedO'Mara TA, Glubb DM, Amant F, Annibali D, Ashton K, Attia J, Auer PL, Beckmann MW, Black A, Bolla MK, Brauch H, Brenner H, Brinton L, Buchanan DD, Burwinkel B, Chang-Claude J, Chanock SJ, Chen C, Chen, Cheng TH, Clarke CL, Clendenning, Cook LS, Couch FJ, Cox A, Crous-Bous, Czene K, Day, Dennis J, Depreeuw J, Doherty JA, Dörk T, Dowdy SC, Dürst M, Ekici AB, Fasching PA, Fridley BL, Friedenreich, Fritschi L, Fung, García-Closas M, Gaudet MM, Giles GG, Goode EL, Gorman M, Haiman CA, Hall P, Hankison, Healey CS, Hein A, Hillemanns P, Hodgson S, Høivik EA, Holliday EG, Hopper JL, Hunter DJ, Jones A, Krakstad C, Kristensen VN, Lambrechts D, Marchand LL, Liang X, Lindblom A, Lissowska J, Long J, Lu L, Magliocco AM, Martin L, McEvoy M, Meindl A, Michailidou K, Milne RL, Mints M, Montgomery GW, Nassir, Olsson H, Orlow I, Otton G, Palles C, Perry JR, Peto J, Pooler, Prescott J, Proietto T, Rebbeck TR, Risch HA, Rogers, Rübner M, Runnebaum I, Sacerdote C, Sarto, Schumacher F, Scott RJ, Setiawan VW, Shah M, Sheng, Shu X, Southey MC, Swerdlow AJ, Tham E, Trovik J, Turman C, Tyrer JP, Vachon C, VanDen Berg, Vanderstichele A, Wang Z, Webb PM, Wentzensen N, Werner HMJ, Winham SJ, Wolk A, Xia L, Xiang Y, Yang HP, Yu H, Zheng W, Pharoah PD, Dunning AM, Kraft P, De Vivo I, Tomlinson I, Easton DF, Spurdle AB, Thompson DJ. Identification of nine new susceptibility loci for endometrial cancer. Nature Communications. 2018;9:3166eng
dc.identifier.issn2041-1723
dc.identifier.urihttps://hdl.handle.net/1956/19910
dc.description.abstractEndometrial cancer is the most commonly diagnosed cancer of the female reproductive tract in developed countries. Through genome-wide association studies (GWAS), we have previously identified eight risk loci for endometrial cancer. Here, we present an expanded meta-analysis of 12,906 endometrial cancer cases and 108,979 controls (including new genotype data for 5624 cases) and identify nine novel genome-wide significant loci, including a locus on 12q24.12 previously identified by meta-GWAS of endometrial and colorectal cancer. At five loci, expression quantitative trait locus (eQTL) analyses identify candidate causal genes; risk alleles at two of these loci associate with decreased expression of genes, which encode negative regulators of oncogenic signal transduction proteins (SH2B3 (12q24.12) and NF1 (17q11.2)). In summary, this study has doubled the number of known endometrial cancer risk loci and revealed candidate causal genes for future study.en_US
dc.language.isoengeng
dc.publisherSpringer Natureeng
dc.rightsAttribution CC BYeng
dc.rights.urihttp://creativecommons.org/licenses/by/4.0eng
dc.titleIdentification of nine new susceptibility loci for endometrial canceren_US
dc.typePeer reviewed
dc.typeJournal article
dc.date.updated2019-03-20T14:54:59Z
dc.description.versionpublishedVersionen_US
dc.rights.holderCopyright 2018 The Author(s)
dc.identifier.doihttps://doi.org/10.1038/s41467-018-05427-7
dc.identifier.cristin1611959
dc.source.journalNature Communications


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