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dc.contributor.authorSzabo, Attilaen_US
dc.contributor.authorGogolák, Péteren_US
dc.contributor.authorKoncz, Gáboren_US
dc.contributor.authorFöldvári, Zsofiaen_US
dc.contributor.authorPazmandi, Kittien_US
dc.contributor.authorMiltner, Noemien_US
dc.contributor.authorPóliska, Szilárden_US
dc.contributor.authorBácsi, Attilaen_US
dc.contributor.authorDjurovic, Srdjanen_US
dc.contributor.authorRajnavölgyi, Évaen_US
dc.PublishedSzabo A, Gogolák, Koncz, Földvári Z, Pazmandi, Miltner, Póliska S, Bácsi, Djurovic S, Rajnavölgyi É. Immunomodulatory capacity of the serotonin receptor 5-HT2B in a subset of human dendritic cells. Scientific Reports. 2018;8:1765eng
dc.description.abstractSerotonin is a monoamine neurotransmitter that signals through a wide array of receptors (5-HT1–7) many of which are also involved in immune processes. Dendritic cells (DCs) are crucial players in immune defense by bridging innate and adaptive immune responses via their vast repertoire of pattern recognition receptors and antigen-presenting capability. Although serotonin is known to influence immunity at many levels, cell type-specific expression and function of its receptors remains poorly understood. Here we aimed to study 5-HT1–7 expression and function in CD1a− and CD1a+ human monocyte-derived DCs (moDCs). We found that the 5-HT2B receptor-subtype is solely expressed by the inflammatory CD1a+ moDC subset. Specific 5-HT2B activation potently inhibited TLR2, TLR3, and TLR7/8-induced proinflammatory cytokine and chemokine (TNF-α, IL-6, IL-8, IP-10, IL-12) but not type I interferon-β responses. 5-HT2B agonism also interfered with the polarization of CD1a+ moDC-primed CD4+ T cells towards inflammatory Th1 and Th17 effector lymphocytes. Here we report the subset-specific expression and immunomodulatory function of 5-HT2B in human moDCs. Our results expand the biological role of 5-HT2B which may act not only as a neurotransmitter receptor, but also as an important modulator of both innate and adaptive immune responses.en_US
dc.publisherSpringer Natureeng
dc.rightsAttribution CC BYeng
dc.titleImmunomodulatory capacity of the serotonin receptor 5-HT2B in a subset of human dendritic cellsen_US
dc.typePeer reviewed
dc.typeJournal article
dc.rights.holderCopyright 2018 The Author(s)
dc.source.journalScientific Reports
dc.relation.projectHelse Sør-Øst RHF: 2018094

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