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dc.contributor.authorDavies, Gailen_US
dc.contributor.authorLam, Maxen_US
dc.contributor.authorHarris, Sarah E.en_US
dc.contributor.authorTrampush, Joey W.en_US
dc.contributor.authorLuciano, Michelleen_US
dc.contributor.authorHill, W. Daviden_US
dc.contributor.authorHagenaars, Saskia P.en_US
dc.contributor.authorRitchie, Stuart J.en_US
dc.contributor.authorMarioni, Riccardo E.en_US
dc.contributor.authorFawns-Ritchie, Chloeen_US
dc.contributor.authorLiewald, David C.M.en_US
dc.contributor.authorOkely, Judith A.en_US
dc.contributor.authorAhola-Olli, Ari V.en_US
dc.contributor.authorBarnes, Catriona L.K.en_US
dc.contributor.authorBertram, Larsen_US
dc.contributor.authorBis, Joshua C.en_US
dc.contributor.authorBurdick, Katherine E.en_US
dc.contributor.authorChristoforou, Andreaen_US
dc.contributor.authorDerosse, Pamelaen_US
dc.contributor.authorDjurovic, Srdjanen_US
dc.contributor.authorEspeseth, Thomasen_US
dc.contributor.authorGiakoumaki, Stellaen_US
dc.contributor.authorGiddaluru, Sudheeren_US
dc.contributor.authorGustavson, Daniel E.en_US
dc.contributor.authorHayward, Carolineen_US
dc.contributor.authorHofer, Edithen_US
dc.contributor.authorIkram, M. Arfanen_US
dc.contributor.authorKarlsson, Roberten_US
dc.contributor.authorKnowles, Emmaen_US
dc.contributor.authorLahti, Jarien_US
dc.contributor.authorLeber, Markusen_US
dc.contributor.authorLi, Shuoen_US
dc.contributor.authorMather, Karen A.en_US
dc.contributor.authorMelle, Ingriden_US
dc.contributor.authorMorris, Dereken_US
dc.contributor.authorOldmeadow, Christopheren_US
dc.contributor.authorPalviainen, Teemuen_US
dc.contributor.authorPayton, Antonyen_US
dc.contributor.authorPazoki, Rahaen_US
dc.contributor.authorPetrovic, Katjaen_US
dc.contributor.authorReynolds, Chandra A.en_US
dc.contributor.authorSargurupremraj, Muralidharanen_US
dc.contributor.authorScholz, Markusen_US
dc.contributor.authorSmith, Jennifer A.en_US
dc.contributor.authorSmith, Albert V.en_US
dc.contributor.authorTerzikhan, Natalieen_US
dc.contributor.authorThalamuthu, Anbupalamen_US
dc.contributor.authorTrompet, Stellaen_US
dc.contributor.authorvan der Lee, Sven J.en_US
dc.contributor.authorWare, Erin B.en_US
dc.contributor.authorWindham, B. Gwenen_US
dc.contributor.authorWright, Margaret J.en_US
dc.contributor.authorYang, Jingyunen_US
dc.contributor.authorYu, Jinen_US
dc.contributor.authorAmes, Daviden_US
dc.contributor.authorAmin, Najafen_US
dc.contributor.authorAmouyel, Philippeen_US
dc.contributor.authorAndreassen, Ole Andreasen_US
dc.contributor.authorArmstrong, Nicola J.en_US
dc.contributor.authorAssareh, Amelia Aen_US
dc.contributor.authorAttia, John R.en_US
dc.contributor.authorAttix, Deborahen_US
dc.contributor.authorAvramopoulos, Dimitriosen_US
dc.contributor.authorBennett, David A.en_US
dc.contributor.authorBöhmer, Anne C.en_US
dc.contributor.authorBoyle, Patricia A.en_US
dc.contributor.authorBrodaty, Henryen_US
dc.contributor.authorCampbell, Harryen_US
dc.contributor.authorCannon, Tyrone D.en_US
dc.contributor.authorCirulli, Elizabeth T.en_US
dc.contributor.authorCongdon, Elizaen_US
dc.contributor.authorConley, Emily Drabanten_US
dc.contributor.authorCorley, Janieen_US
dc.contributor.authorCox, Simon R.en_US
dc.contributor.authorDale, Andersen_US
dc.contributor.authorDehghan, Abbasen_US
dc.contributor.authorDick, Danielleen_US
dc.contributor.authorDickinson, Dwighten_US
dc.contributor.authorEriksson, Johan G.en_US
dc.contributor.authorEvangelou, Evangelosen_US
dc.contributor.authorFaul, Jessica D.en_US
dc.contributor.authorFord, Ianen_US
dc.contributor.authorFreimer, Nelson A.en_US
dc.contributor.authorGao, Heen_US
dc.contributor.authorGiegling, Inaen_US
dc.contributor.authorGillespie, Nathan A.en_US
dc.contributor.authorGordon, Scott D.en_US
dc.contributor.authorGottesman, Rebecca F.en_US
dc.contributor.authorGriswold, Michael E.en_US
dc.contributor.authorGudnason, Vilmunduren_US
dc.contributor.authorHarris, Tamara B.en_US
dc.contributor.authorHartmann, Annette M.en_US
dc.contributor.authorHatzimanolis, Alexen_US
dc.contributor.authorHeiss, Gerardoen_US
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dc.contributor.authorKähönen, Mikaen_US
dc.contributor.authorKardia, Sharon L.R.en_US
dc.contributor.authorKarlsson, Idaen_US
dc.contributor.authorKleineidam, Lucaen_US
dc.contributor.authorKnopman, David S.en_US
dc.contributor.authorKochan, Nicole A.en_US
dc.contributor.authorKonte, Bettinaen_US
dc.contributor.authorKwok, John B.en_US
dc.contributor.authorLe Hellard, Stephanieen_US
dc.contributor.authorLee, Teresaen_US
dc.contributor.authorLehtimäki, Terhoen_US
dc.contributor.authorLi, Shu-Chenen_US
dc.contributor.authorLiu, Tianen_US
dc.contributor.authorKoini, Marisaen_US
dc.contributor.authorLondon, Edytheen_US
dc.contributor.authorLongstreth, Will T.en_US
dc.contributor.authorLopez, Oscar L.en_US
dc.contributor.authorLoukola, Anuen_US
dc.contributor.authorLuck, Tobiasen_US
dc.contributor.authorLundervold, Astrien_US
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dc.contributor.authorLyytikäinen, Leo-Pekkaen_US
dc.contributor.authorMartin, Nicholas G.en_US
dc.contributor.authorMontgomery, Grant W.en_US
dc.contributor.authorMurray, Alison D.en_US
dc.contributor.authorNeed, Anna C.en_US
dc.contributor.authorNoordam, Raymonden_US
dc.contributor.authorNyberg, Larsen_US
dc.contributor.authorOllier, Williamen_US
dc.contributor.authorPapenberg, Göranen_US
dc.contributor.authorPattie, Alisonen_US
dc.contributor.authorPolasek, Ozrenen_US
dc.contributor.authorPoldrack, Russell A.en_US
dc.contributor.authorPsaty, Bruce M.en_US
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dc.contributor.authorRose, Richard J.en_US
dc.contributor.authorRotter, Jerome I.en_US
dc.contributor.authorRoussos, Panosen_US
dc.contributor.authorRovio, Suvi P.en_US
dc.contributor.authorSaba, Yasamanen_US
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dc.contributor.authorSachdev, Perminder S.en_US
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dc.contributor.authorSchmid, Matthiasen_US
dc.contributor.authorScott, Rodney J.en_US
dc.contributor.authorScult, Matthew A.en_US
dc.contributor.authorSimino, Jeannetteen_US
dc.contributor.authorSlagboom, P. Elineen_US
dc.contributor.authorSmyrnis, Nikolaosen_US
dc.contributor.authorSoumaré, Aïchaen_US
dc.contributor.authorStefanis, Nikos C.en_US
dc.contributor.authorStott, David J.en_US
dc.contributor.authorStraub, Richard E.en_US
dc.contributor.authorSundet, Kjetil Sørenen_US
dc.contributor.authorTaylor, Adele M.en_US
dc.contributor.authorTaylor, Kent D.en_US
dc.contributor.authorTzoulaki, Ioannaen_US
dc.contributor.authorTzourio, Christopheen_US
dc.contributor.authorUitterlinden, Andréen_US
dc.contributor.authorVitart, Veroniqueen_US
dc.contributor.authorVoineskos, Aristotle N.en_US
dc.contributor.authorKaprio, Jaakkoen_US
dc.contributor.authorWagner, Michaelen_US
dc.contributor.authorWagner, Holgeren_US
dc.contributor.authorWeinhold, Leonieen_US
dc.contributor.authorWen, K. Hoyanen_US
dc.contributor.authorWidén, Elisabethen_US
dc.contributor.authorYang, Qiongen_US
dc.contributor.authorZhao, Weien_US
dc.contributor.authorAdams, Hieab H.H.en_US
dc.contributor.authorArking, Dan E.en_US
dc.contributor.authorBilder, Robert M.en_US
dc.contributor.authorBitsios, Panosen_US
dc.contributor.authorBoerwinkle, Ericen_US
dc.contributor.authorChiba-Falek, Orniten_US
dc.contributor.authorCorvin, Aidenen_US
dc.contributor.authorDe Jager, Philip L.en_US
dc.contributor.authorDebette, Stéphanieen_US
dc.contributor.authorDonohoe, Garyen_US
dc.contributor.authorElliott, Paulen_US
dc.contributor.authorFitzpatrick, Annette L.en_US
dc.contributor.authorGill, Michaelen_US
dc.contributor.authorGlahn, David C.en_US
dc.contributor.authorHägg, Saraen_US
dc.contributor.authorHansell, Narelle K.en_US
dc.contributor.authorHariri, Ahmaden_US
dc.contributor.authorIkram, M. Kamranen_US
dc.contributor.authorJukema, J. Wouteren_US
dc.contributor.authorVuoksimaa, Eeroen_US
dc.contributor.authorKeller, Matthew C.en_US
dc.contributor.authorKremen, William S.en_US
dc.contributor.authorLauner, Lenoreen_US
dc.contributor.authorLindenberger, Ulmanen_US
dc.contributor.authorPalotie, Aarnoen_US
dc.contributor.authorPedersen, Nancy L.en_US
dc.contributor.authorPendleton, Neilen_US
dc.contributor.authorPorteous, David J.en_US
dc.contributor.authorRäikkönen, Katrien_US
dc.contributor.authorRaitakari, Olli T.en_US
dc.contributor.authorRamirez, Alfredoen_US
dc.contributor.authorReinvang, Ivaren_US
dc.contributor.authorRudan, Igoren_US
dc.contributor.authorRujescu, Danen_US
dc.contributor.authorSchmidt, Reinholden_US
dc.contributor.authorSchmidt, Helenaen_US
dc.contributor.authorSchofield, Peter W.en_US
dc.contributor.authorSchofield, Peter R.en_US
dc.contributor.authorStarr, John M.en_US
dc.contributor.authorSteen, Vidar Martinen_US
dc.contributor.authorTrollor, Julian N.en_US
dc.contributor.authorTurner, Steven T.en_US
dc.contributor.authorVan Duijn, Cornelia M.en_US
dc.contributor.authorVillringer, Arnoen_US
dc.contributor.authorWeinberger, Daniel R.en_US
dc.contributor.authorWeir, David R.en_US
dc.contributor.authorWilson, James F.en_US
dc.contributor.authorMalhotra, Anilen_US
dc.contributor.authorMcIntosh, Andrew M.en_US
dc.contributor.authorGale, Catharine R.en_US
dc.contributor.authorSeshadri, Sudhaen_US
dc.contributor.authorMosley, Thomas H.en_US
dc.contributor.authorBressler, Janen_US
dc.contributor.authorLencz, Todden_US
dc.contributor.authorDeary, Ian J.en_US
dc.date.accessioned2019-07-03T12:49:23Z
dc.date.available2019-07-03T12:49:23Z
dc.date.issued2018
dc.PublishedDavies G et al. Study of 300,486 individuals identifies 148 independent genetic loci influencing general cognitive function. Nature Communications. 2018;9:2098eng
dc.identifier.issn2041-1723
dc.identifier.urihttps://hdl.handle.net/1956/20548
dc.description.abstractGeneral cognitive function is a prominent and relatively stable human trait that is associated with many important life outcomes. We combine cognitive and genetic data from the CHARGE and COGENT consortia, and UK Biobank (total N = 300,486; age 16–102) and find 148 genome-wide significant independent loci (P < 5 × 10−8) associated with general cognitive function. Within the novel genetic loci are variants associated with neurodegenerative and neurodevelopmental disorders, physical and psychiatric illnesses, and brain structure. Gene-based analyses find 709 genes associated with general cognitive function. Expression levels across the cortex are associated with general cognitive function. Using polygenic scores, up to 4.3% of variance in general cognitive function is predicted in independent samples. We detect significant genetic overlap between general cognitive function, reaction time, and many health variables including eyesight, hypertension, and longevity. In conclusion we identify novel genetic loci and pathways contributing to the heritability of general cognitive function.en_US
dc.language.isoengeng
dc.publisherNature Researcheng
dc.rightsAttribution CC BYeng
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/eng
dc.titleStudy of 300,486 individuals identifies 148 independent genetic loci influencing general cognitive functionen_US
dc.typePeer reviewed
dc.typeJournal article
dc.date.updated2019-02-12T09:48:48Z
dc.description.versionpublishedVersionen_US
dc.rights.holderCopyright 2018 The Authors
dc.identifier.doihttps://doi.org/10.1038/s41467-018-04362-x
dc.identifier.cristin1593018
dc.source.journalNature Communications
dc.relation.projectStiftelsen Kristian Gerhard Jebsen: SKGJ-MED-008
dc.relation.projectNorges forskningsråd: 223273


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