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dc.contributor.authorBeaumont, Robin N.en_US
dc.contributor.authorWarrington, Nicole M.en_US
dc.contributor.authorCavadino, Alanaen_US
dc.contributor.authorTyrrell, Jessicaen_US
dc.contributor.authorNodzenski, Michaelen_US
dc.contributor.authorHorikoshi, Momokoen_US
dc.contributor.authorGeller, Franken_US
dc.contributor.authorMyhre, Ronnyen_US
dc.contributor.authorRichmond, Rebecca C.en_US
dc.contributor.authorPaternoster, Laviniaen_US
dc.contributor.authorBradfield, Jonathan P.en_US
dc.contributor.authorKreiner-Møller, Eskilen_US
dc.contributor.authorHuikari, Villeen_US
dc.contributor.authorMetrustry, Sarahen_US
dc.contributor.authorLunetta, Kathryn L.en_US
dc.contributor.authorPainter, Jodie N.en_US
dc.contributor.authorHottenga, Jouke-Janen_US
dc.contributor.authorAllard, Catherineen_US
dc.contributor.authorBarton, Sheila J.en_US
dc.contributor.authorEspinosa, Anaen_US
dc.contributor.authorMarsh, Julie A.en_US
dc.contributor.authorPotter, Catherineen_US
dc.contributor.authorZhang, Geen_US
dc.contributor.authorAng, Weien_US
dc.contributor.authorBerry, Diane J.en_US
dc.contributor.authorBouchard, Luigien_US
dc.contributor.authorDas, Shiktaen_US
dc.contributor.authorHakonarson, Hakonen_US
dc.contributor.authorHeikkinen, Janien_US
dc.contributor.authorHelgeland, Øyvinden_US
dc.contributor.authorHocher, Bertholden_US
dc.contributor.authorHofman, Alberten_US
dc.contributor.authorInskip, Hazel M.en_US
dc.contributor.authorJones, Samuel E.en_US
dc.contributor.authorKogevinas, Manolisen_US
dc.contributor.authorLind, Penelope A.en_US
dc.contributor.authorMarullo, Letiziaen_US
dc.contributor.authorMedland, Sarah E.en_US
dc.contributor.authorMurray, Annaen_US
dc.contributor.authorMurray, Jeffrey C.en_US
dc.contributor.authorNjølstad, Pål Rasmusen_US
dc.contributor.authorNohr, Ellen A.en_US
dc.contributor.authorReichetzeder, Christophen_US
dc.contributor.authorRing, Susan M.en_US
dc.contributor.authorRuth, Katherine S.en_US
dc.contributor.authorSanta-Marina, Loretoen_US
dc.contributor.authorScholtens, Denise M.en_US
dc.contributor.authorSebert, Sylvainen_US
dc.contributor.authorSengpiel, Verenaen_US
dc.contributor.authorTuke, Marcus A.en_US
dc.contributor.authorVaudel, Marcen_US
dc.contributor.authorWeedon, Michael N.en_US
dc.contributor.authorWillemsen, Gonnekeen_US
dc.contributor.authorWood, Andrew R.en_US
dc.contributor.authorYaghootkar, Haniehen_US
dc.contributor.authorMuglia, Louis J.en_US
dc.contributor.authorBartels, Meikeen_US
dc.contributor.authorRelton, Caroline L.en_US
dc.contributor.authorPennell, Craig E.en_US
dc.contributor.authorChatzi, Ledaen_US
dc.contributor.authorEstivill, Xavieren_US
dc.contributor.authorHolloway, John W.en_US
dc.contributor.authorBoomsma, Dorret I.en_US
dc.contributor.authorMontgomery, Grant W.en_US
dc.contributor.authorMurabito, Joanne M.en_US
dc.contributor.authorSpector, Tim D.en_US
dc.contributor.authorPower, Christineen_US
dc.contributor.authorJärvelin, Marjo-Riittaen_US
dc.contributor.authorBisgaard, Hansen_US
dc.contributor.authorGrant, Struan F.A.en_US
dc.contributor.authorSørensen, Thorkild I.A.en_US
dc.contributor.authorJaddoe, Vincent W.en_US
dc.contributor.authorJacobsson, Boen_US
dc.contributor.authorMelbye, Madsen_US
dc.contributor.authorMcCarthy, Mark I.en_US
dc.contributor.authorHattersley, Andrew T.en_US
dc.contributor.authorHayes, M. Geoffreyen_US
dc.contributor.authorHivert, Marie-Franceen_US
dc.contributor.authorFrayling, Timothy M.en_US
dc.contributor.authorFelix, Janine F.en_US
dc.contributor.authorHyppönen, Elinaen_US
dc.contributor.authorLowe, William L.en_US
dc.contributor.authorEvans, David M.en_US
dc.contributor.authorLawlor, Debbie A.en_US
dc.contributor.authorFeenstra, Bjarkeen_US
dc.contributor.authorFreathy, Rachel M.en_US
dc.PublishedBeaumont, Warrington NM, Cavadino A, Tyrrell J, Nodzenski M, Horikoshi M, Geller F, Myhre R, Richmond RC, Paternoster L, Bradfield JP, Kreiner-Møller E, Huikari V, Metrustry S, Lunetta KL, Painter JN, Hottenga J, Allard C, Barton SJ, Espinosa, Marsh, Potter, Zhang G, Ang W, Berry DJ, Bouchard L, Das S, Hakonarson H, Heikkinen J, Helgeland Ø, Hocher B, Hofman A, Inskip HM, Jones, Kogevinas M, Lind PA, Marullo, Medland SE, Murray A, Murray JC, Njølstad PR, Nohr EA, Reichetzeder C, Ring SM, Ruth KS, Santa-Marina L, Scholtens DM, Sebert S, Sengpiel V, Tuke, Vaudel M, Weedon MN, Willemsen G, Wood AR, Yaghootkar H, Muglia, Bartels M, Relton CL, Pennell CE, Chatzi L, Estivill X, Holloway JW, Boomsma DI, Montgomery GW, Murabito, Spector TD, Power C, Järvelin M, Bisgaard H, Grant SF, Sørensen TI, Jaddoe VW, Jacobsson BG, Melbye M, McCarthy MI, Hattersley AT, Hayes MG, Hivert M, Frayling TM, Felix JF, Hyppönen E, Lowe WL, Evans DM, Lawlor DA, Feenstra B, Freathy RM. Genome-wide association study of offspring birth weight in 86 577 women identifies five novel loci and highlights maternal genetic effects that are independent of fetal genetics. Human Molecular Genetics. 2018;27(4):742-756eng
dc.description.abstractGenome-wide association studies of birth weight have focused on fetal genetics, whereas relatively little is known about the role of maternal genetic variation. We aimed to identify maternal genetic variants associated with birth weight that could highlight potentially relevant maternal determinants of fetal growth. We meta-analysed data on up to 8.7 million SNPs in up to 86 577 women of European descent from the Early Growth Genetics (EGG) Consortium and the UK Biobank. We used structural equation modelling (SEM) and analyses of mother–child pairs to quantify the separate maternal and fetal genetic effects. Maternal SNPs at 10 loci (MTNR1B, HMGA2, SH2B3, KCNAB1, L3MBTL3, GCK, EBF1, TCF7L2, ACTL9, CYP3A7) were associated with offspring birth weight at P < 5 × 10−8. In SEM analyses, at least 7 of the 10 associations were consistent with effects of the maternal genotype acting via the intrauterine environment, rather than via effects of shared alleles with the fetus. Variants, or correlated proxies, at many of the loci had been previously associated with adult traits, including fasting glucose (MTNR1B, GCK and TCF7L2) and sex hormone levels (CYP3A7), and one (EBF1) with gestational duration. The identified associations indicate that genetic effects on maternal glucose, cytochrome P450 activity and gestational duration, and potentially on maternal blood pressure and immune function, are relevant for fetal growth. Further characterization of these associations in mechanistic and causal analyses will enhance understanding of the potentially modifiable maternal determinants of fetal growth, with the goal of reducing the morbidity and mortality associated with low and high birth weights.en_US
dc.publisherOxford University Presseng
dc.rightsAttribution CC BYeng
dc.titleGenome-wide association study of offspring birth weight in 86 577 women identifies five novel loci and highlights maternal genetic effects that are independent of fetal geneticsen_US
dc.typePeer reviewed
dc.typeJournal article
dc.rights.holderCopyright 2018 The Author(s)
dc.source.journalHuman Molecular Genetics

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