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dc.contributor.authorDhillon, Amandeep Kauren_US
dc.contributor.authorKremer, Andreas E.en_US
dc.contributor.authorKummen, Martinen_US
dc.contributor.authorBoberg, Kirsten Murien_US
dc.contributor.authorElferink, Ronald P. Oudeen_US
dc.contributor.authorKarlsen, Tom Hemmingen_US
dc.contributor.authorBeuers, Ulrichen_US
dc.contributor.authorVesterhus, Metteen_US
dc.contributor.authorHov, Johannes Espolin Roksunden_US
dc.PublishedDhillon AK, Kremer, Kummen M, Boberg KM, Elferink, Karlsen HT, Beuers U, Vesterhus M, Hov JR. Autotaxin activity predicts transplant-free survival in primary sclerosing cholangitis. Scientific Reports. 2019;9:8450.eng
dc.description.abstractAutotaxin has been associated with liver disease severity and transplant-free survival. This study aimed to validate autotaxin as a biomarker in two cohorts of Norwegian large-duct PSC patients, one discovery panel (n=165) and one validation panel (n=87). Serum activity of autotaxin was measured in diluted sera by a fuorometric enzymatic assay. Patients reaching an end-point, liver transplantation or death, (discovery panel: n=118 [71.5%]; validation panel: n=35 [40.2%]), showed higher autotaxin activity compared with the other patients, P<0.001 and P=0.004, respectively. Kaplan-Meier survival analyses showed a strong association between increasing autotaxin activity and shorter liver transplant-free survival (discovery panel: P<0.001, validation panel: P=0.001). There was no relationship between autotaxin activity and the presence of infammatory bowel disease or occurrence of hepatobiliary malignancy. In a multivariable analysis, high autotaxin activity was associated with an increased risk of liver transplantation or death (hazard ratio 2.03 (95% confdence interval 1.21–3.40), P<0.01), independent from Mayo risk score, an in-house enhanced liver fbrosis score and interleukin-8 in serum. In conclusion, increased serum autotaxin activity is associated with reduced liver transplantfree survival independent from Mayo risk score and markers of infammation and fbrosis.en_US
dc.publisherNature Researcheng
dc.rightsAttribution CC BYeng
dc.titleAutotaxin activity predicts transplant-free survival in primary sclerosing cholangitisen_US
dc.typePeer reviewed
dc.typeJournal article
dc.rights.holderCopyright The Author(s) 2019
dc.source.journalScientific Reports

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