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dc.contributor.authorKonateh, Bakary-Jang
dc.date.accessioned2019-10-08T06:53:42Z
dc.date.available2019-10-08T06:53:42Z
dc.date.issued2019-10-03
dc.date.submitted2019-10-02T22:00:03Z
dc.identifier.urihttps://hdl.handle.net/1956/20909
dc.description.abstractThe β-hydroxy dithiane, 3-(1,3-dithiane-2-yl)-1,1-diethoxypropan-2-ol, was synthesized from the versatile synthon 3,3,4,4-tetraethoxybut-1-yne (TEB). 1,1-Diethoxy-3-(2-methyl-1,3- dithian-2-yl)propan-2-ol was successfully formed in low yield (13%) by an alkylation reaction involving the dithiane and MeI in the presence of n-BuLi. An attempt at a silylation reaction using the dithiane failed to produce the trimethylsilyl protected hydroxy derivative. Hydrolysis of the benzyl protected β-hydroxy dithiane was successful (35%) but attempted chain elongation of the corresponding aldehyde using Wittig olefination failed. Alternative procedures for synthesizing 1,1-diethoxybut-3-yn-2-one (TEB-ketone), needed in the formation of the β-hydroxy dithiane, were explored. As a result, a new a three-step method for generating the TEB-ketone was developed. A novel four-step synthesis of the β-hydroxy dithiane from easily available and inexpensive ethyl 2,2-diethoxyacetate is also described.en_US
dc.language.isoeng
dc.publisherThe University of Bergenen_US
dc.rightsCopyright the Author. All rights reserved
dc.titleTowards the Synthesis of β-Hydroxy 1,3-Dithiane Derivatives
dc.typeMaster thesis
dc.date.updated2019-10-02T22:00:03Z
dc.rights.holderCopyright the Author. All rights reserveden_US
dc.description.degreeMasteroppgave i kjemien_US
dc.description.localcodeKJEM399
dc.description.localcodeMAMN-KJEM
dc.subject.nus752299
fs.subjectcodeKJEM399
fs.unitcode12-31-0


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