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dc.contributor.authorVerheggen, Kennethen_US
dc.contributor.authorRæder, Helgeen_US
dc.contributor.authorBerven, Frodeen_US
dc.contributor.authorMartens, Lennart Martensen_US
dc.contributor.authorBarsnes, Haralden_US
dc.contributor.authorVaudel, Marcen_US
dc.date.accessioned2019-11-19T08:46:10Z
dc.date.available2019-11-19T08:46:10Z
dc.date.issued2017-09-13
dc.PublishedVerheggen K, Ræder H, Berven F, Martens LM, Barsnes H, Vaudel M. Anatomy and evolution of database search engines—a central component of mass spectrometry based proteomic workflows. Mass spectrometry reviews 2017:1-15.eng
dc.identifier.issn0277-7037
dc.identifier.issn1098-2787
dc.identifier.urihttps://hdl.handle.net/1956/21005
dc.description.abstractSequence database search engines are bioinformatics algorithms that identify peptides from tandem mass spectra using a reference protein sequence database. Two decades of development, notably driven by advances in mass spectrometry, have provided scientists with more than 30 published search engines, each with its own properties. In this review, we present the common paradigm behind the different implementations, and its limitations for modern mass spectrometry datasets. We also detail how the search engines attempt to alleviate these limitations, and provide an overview of the different software frameworks available to the researcher. Finally, we highlight alternative approaches for the identification of proteomic mass spectrometry datasets, either as a replacement for, or as a complement to, sequence database search engines.en_US
dc.language.isoengeng
dc.publisherWileyeng
dc.subjectBioinformaticseng
dc.subjectProteomicseng
dc.subjectSearch engineeng
dc.titleAnatomy and evolution of database search engines — a central component of mass spectrometry based proteomic workflowsen_US
dc.typePeer reviewed
dc.typeJournal article
dc.date.updated2019-08-29T13:24:08Z
dc.description.versionacceptedVersionen_US
dc.rights.holderCopyright 2017 Wiley Periodicals, Inc.
dc.identifier.doihttps://doi.org/10.1002/mas.21543
dc.identifier.cristin1548967
dc.source.journalMass spectrometry reviews (Print)
dc.relation.projectBergens forskningsstiftelse: BFS2016REK02
dc.relation.projectNorges forskningsråd: 251235


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