dc.contributor.author | Jacobsen, Daniel Pitz | |
dc.contributor.author | Eriksen, Mina Baarnes | |
dc.contributor.author | Rajalingam, Dhaksshaginy | |
dc.contributor.author | Nymoen, Ingeborg | |
dc.contributor.author | Nielsen, Morten Birkeland | |
dc.contributor.author | Einarsen, Ståle | |
dc.contributor.author | Gjerstad, Johannes | |
dc.date.accessioned | 2019-12-11T10:01:17Z | |
dc.date.available | 2019-12-11T10:01:17Z | |
dc.date.issued | 2019 | |
dc.Published | Jacobsen DP, Eriksen MB, Rajalingam D, Nymoen I, Nielsen MB, Einarsen S, Gjerstad J. Exposure to workplace bullying, microRNAs and pain. Evidence of a moderating effect of miR-30c rs928508 and miR-223 rs3848900. Stress. 2019 | eng |
dc.identifier.issn | 1025-3890 | |
dc.identifier.issn | 1607-8888 | |
dc.identifier.uri | https://hdl.handle.net/1956/21080 | |
dc.description.abstract | Prolonged exposure to bullying behaviors may give rise to symptoms such as anxiety, depression and chronic pain. Earlier data suggest that these symptoms often are associated with stress-induced low-grade systemic inflammation. Here, using data from both animals and humans, we examined the moderating role of microRNAs (miRNAs, miRs) in this process. In the present study, a resident-intruder paradigm, blood samples, tissue harvesting and subsequent qPCR analyses were used to screen for stress-induced changes in circulating miRNAs in rats. The negative acts questionnaire (NAQ), TaqMan assays and a numeric rating scale (NRS) for pain intensity were then used to examine the associations among bullying behaviors, relevant miRNA polymorphisms and pain in a probability sample of 996 Norwegian employees. In rats, inhibited weight gain, reduced pituitary POMC expression, adrenal Nr3c1 mRNA downregulation, as well as increased miR-146a, miR-30c and miR-223 in plasma were observed following 1 week of repeated exposure to social stress. When following up the miRNA findings from the animal study in the human working population, a stronger relationship between NAQ and NRS scores was observed in subjects with the miR-30c GG genotype (rs928508) compared to other subjects. A stronger relationship between NAQ and NRS scores was also seen in men with the miR-223 G genotype (rs3848900) as compared to other men. Our findings show that social stress may induce many physiological changes including changed expression of miRNAs. We conclude that the miR-30c GG genotype in men and women, and the miR-223 G genotype in men, amplify the association between exposure to bullying behaviors and pain. | en_US |
dc.language.iso | eng | eng |
dc.publisher | Taylor & Francis | eng |
dc.rights | Attribution CC BY-NC-ND | eng |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | eng |
dc.subject | Social stress | eng |
dc.subject | miRNA | eng |
dc.subject | Pain | eng |
dc.subject | Rat | eng |
dc.subject | Human | eng |
dc.subject | Genotype | eng |
dc.subject | SNP | eng |
dc.title | Exposure to workplace bullying, microRNAs and pain. Evidence of a moderating effect of miR-30c rs928508 and miR-223 rs3848900 | eng |
dc.type | Peer reviewed | |
dc.type | Journal article | |
dc.date.updated | 2019-08-23T06:37:18Z | |
dc.description.version | publishedVersion | |
dc.rights.holder | Copyright 2019 The Author(s) | eng |
dc.identifier.doi | https://doi.org/10.1080/10253890.2019.1642320 | |
dc.identifier.cristin | 1713351 | |
dc.source.journal | Stress | |