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dc.contributor.authorAraujo, Pedroen_US
dc.contributor.authorBelghit, Ikramen_US
dc.contributor.authorAarsaether, Nielsen_US
dc.contributor.authorEspe, Mariten_US
dc.contributor.authorLucena, Evaen_US
dc.contributor.authorHolen, Elisabethen_US
dc.PublishedAraujo A, Belghit I, Aarsaether N, Espe M, Lucena EM, Holen E. The effect of omega-3 and omega-6 polyunsaturated fatty acids on the production of cyclooxygenase and lipoxygenase metabolites by human umbilical vein endothelial cells. Nutrients. 2019;11(5):966eng
dc.description.abstractAlthough the correlation between polyunsaturated fatty acids (PUFA) and the production of pro- and anti-inflammatory metabolites is well documented, little is known about the simultaneous effect of different PUFA on the production of cyclooxygenase and lipoxygenase metabolites. The present research examines the association between different omega-3 (ω-3) and omega-6 (ω-6) PUFA and the release of four cyclooxygenase and six lipoxygenase metabolites in cell medium by human umbilical vein endothelial cells (HUVEC). The different combinations of ω-3 and ω-6 PUFA were prepared according to a full 24 factorial design that enables studying not only the main effects but also the different interactions between fatty acids. In addition, interactions diagrams and principal component analysis were useful tools for interpreting higher order interactions. To the best of our knowledge, this is the first report addressing the combined effect of ω-3 and ω-6 PUFA on the signaling of prostaglandins, prostacyclins, leukotrienes and resolvins by HUVEC.en_US
dc.rightsAttribution CC BYeng
dc.subjectpolyunsaturated fatty acids
dc.subjectdocosahexaenoic acid
dc.subjecteicosapentaenoic acid
dc.subjectα-linolenic acid
dc.subjectarachidonic acid
dc.subjecthuman umbilical vein endothelial cells
dc.titleThe effect of omega-3 and mega-6 polyunsaturated fatty acids on the production of cyclooxygenase and lipoxygenase metabolites by human umbilical vein endothelial cellsen_US
dc.typePeer reviewed
dc.typeJournal article
dc.rights.holderCopyright 2019 The Authors

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