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dc.contributor.authorRongve, Arviden_US
dc.contributor.authorWitoelar, Areeen_US
dc.contributor.authorRuiz, Agustínen_US
dc.contributor.authorAthanasiu, Laviniaen_US
dc.contributor.authorAbdelnour, Carlaen_US
dc.contributor.authorClarimon, Jordien_US
dc.contributor.authorHeilmann-Heimbach, Stefanieen_US
dc.contributor.authorHernández, Isabelen_US
dc.contributor.authorMoreno-Grau, Soniaen_US
dc.contributor.authorde Rojas, Itziaren_US
dc.contributor.authorMorenas-Rodríguez, Estrellaen_US
dc.contributor.authorFladby, Tormoden_US
dc.contributor.authorSando, Sigrid Botneen_US
dc.contributor.authorBråthen, Geiren_US
dc.contributor.authorBlanc, Frédéricen_US
dc.contributor.authorBousiges, Olivieren_US
dc.contributor.authorLemstra, Afina W.en_US
dc.contributor.authorvan Steenoven, Ingeren_US
dc.contributor.authorLondos, Elisabeten_US
dc.contributor.authorAlmdahl, Ina Selsethen_US
dc.contributor.authorPålhaugen, Leneen_US
dc.contributor.authorEriksen, Jon Almen_US
dc.contributor.authorDjurovic, Srdjanen_US
dc.contributor.authorStordal, Eysteinen_US
dc.contributor.authorSaltvedt, Ingvilden_US
dc.contributor.authorUlstein, Ingunen_US
dc.contributor.authorBettella, Francescoen_US
dc.contributor.authorDesikan, Rahul S.en_US
dc.contributor.authorIdland, Ane-Victoriaen_US
dc.contributor.authorToft, Mathiasen_US
dc.contributor.authorPihlstrøm, Lasseen_US
dc.contributor.authorSnaedal, Jonen_US
dc.contributor.authorTárraga, Lluísen_US
dc.contributor.authorBoada, Mercèen_US
dc.contributor.authorLleó, Albertoen_US
dc.contributor.authorStefánsson, Hreinnen_US
dc.contributor.authorStefánsson, Kárien_US
dc.contributor.authorRamírez, Alfredoen_US
dc.contributor.authorAarsland, Dagen_US
dc.contributor.authorAndreassen, Ole Andreasen_US
dc.PublishedRongve A, Witoelar AW, Ruiz, Athanasiu L, Abdelnour C, Clarimon J, Heilmann-Heimbach S, Hernández, Moreno-Grau, de Rojas, Morenas-Rodríguez, Fladby T, Sando SB, Bråthen GBr, Blanc F, Bousiges, Lemstra AW, van Steenoven, Londos E, Almdahl I, Pålhaugen L, Eriksen JA, Djurovic S, Stordal E, Saltvedt IS, Ulstein I, Bettella F, Desikan RS, Idland A, Toft M, Pihlstrøm L, Snaedal J, Tárraga, Boada M, Lleó A, Stefánsson H, Stefánsson K, Ramírez, Aarsland D, Andreassen OA. GBA and APOE ε4 associate with sporadic dementia with Lewy bodies in European genome wide association study. Scientific Reports. 2019;9:7013.eng
dc.description.abstractDementia with Lewy Bodies (DLB) is a common neurodegenerative disorder with poor prognosis and mainly unknown pathophysiology. Heritability estimates exceed 30% but few genetic risk variants have been identified. Here we investigated common genetic variants associated with DLB in a large European multisite sample. We performed a genome wide association study in Norwegian and European cohorts of 720 DLB cases and 6490 controls and included 19 top-associated single-nucleotide polymorphisms in an additional cohort of 108 DLB cases and 75545 controls from Iceland. Overall the study included 828 DLB cases and 82035 controls. Variants in the ASH1L/GBA (Chr1q22) and APOE ε4 (Chr19) loci were associated with DLB surpassing the genome-wide significance threshold (p < 5 × 10−8). One additional genetic locus previously linked to psychosis in Alzheimer’s disease, ZFPM1 (Chr16q24.2), showed suggestive association with DLB at p-value < 1 × 10−6. We report two susceptibility loci for DLB at genome-wide significance, providing insight into etiological factors. These findings highlight the complex relationship between the genetic architecture of DLB and other neurodegenerative disorders.en_US
dc.publisherNature Researcheng
dc.rightsAttribution CC BY 4.0eng
dc.titleGBA and APOE ε4 associate with sporadic dementia with Lewy bodies in European genome wide association studyen_US
dc.typePeer reviewed
dc.typeJournal article
dc.rights.holderCopyright 2019 The Author(s)
dc.source.journalScientific Reports

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