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dc.contributor.authorBlytt, Kjersti Marieen_US
dc.contributor.authorBjorvatn, Bjørnen_US
dc.contributor.authorHusebø, Bettinaen_US
dc.contributor.authorFlo, Elisabethen_US
dc.date.accessioned2020-02-17T13:22:55Z
dc.date.available2020-02-17T13:22:55Z
dc.date.issued2018-12-28
dc.PublishedBlytt k, Bjorvatn B, Husebø BS, Flo E. Effects of pain treatment on sleep in nursing home patients with dementia and depression: A multicenter placebo-controlled randomized clinical trial. International Journal of Geriatric Psychiatry. 2018;33(4):663-670.eng
dc.identifier.issn1099-1166
dc.identifier.issn0885-6230
dc.identifier.urihttps://hdl.handle.net/1956/21424
dc.description.abstractObjective: To investigate the effects of pain treatment on sleep in nursing home (NH) patients with dementia and depression. Methods: A multicenter, 2‐armed, double‐blinded, placebo‐controlled, randomized clinical trial conducted between August 2014 and September 2016. One hundred six long‐term patients from 47 NHs in Norway with dementia and depression according to the Mini‐Mental State Examination and the Cornell Scale for Depression in Dementia were included. Patients received stepwise pain treatment in which those who did not use analgesics were randomized to receive either paracetamol (3 g/day) or placebo tablets; those who already used pain treatment were allocated to buprenorphine transdermal system (max. 10 μg/h/7 days) or placebo transdermal patches. Sleep was assessed continuously for 14 days by actigraphy, 1 week of baseline measurement, and 1 week of ongoing treatment. The following sleep parameters were evaluated: total sleep time, sleep efficiency (SE), sleep onset latency (SOL), wake after sleep onset, early morning awakening (EMA), and number of wake bouts. Results: In the intervention group (paracetamol/buprenorphine), SE (70%‐72%), SOL (32‐24 min), and EMA (50‐40 min) improved compared with the control group (SE, 70%‐67%; SOL, 47‐60 min; EMA, 31‐35 min). Treatment effects were significant (P < .01, P < .05, and P < .05, respectively). Conclusion: Compared with placebo, pain treatment improved sleep as measured with actigraphy. This implies that sleep, pain, and depression in NH patients should be critically evaluated and that pain treatment should be considered to be a potentially beneficial treatment.en_US
dc.language.isoengeng
dc.publisherWileyeng
dc.rightsAttribution-NonCommercial-NoDerivs CC BY-NC-ND 4.0eng
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/eng
dc.subjectActigraphyeng
dc.subjectDementiaeng
dc.subjectDepressioneng
dc.subjectNursing homeeng
dc.subjectPain treatmenteng
dc.subjectSleepeng
dc.titleEffects of pain treatment on sleep in nursing home patients with dementia and depression: A multicenter placebo-controlled randomized clinical trialen_US
dc.typePeer reviewed
dc.typeJournal article
dc.date.updated2019-09-13T09:34:22Z
dc.description.versionpublishedVersionen_US
dc.rights.holderCopyright 2017 The Authors.
dc.identifier.doihttps://doi.org/10.1002/gps.4839
dc.identifier.cristin1590480
dc.source.journalInternational Journal of Geriatric Psychiatry


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Attribution-NonCommercial-NoDerivs CC BY-NC-ND 4.0
Except where otherwise noted, this item's license is described as Attribution-NonCommercial-NoDerivs CC BY-NC-ND 4.0