Co-translational, post-translational, and non-catalytic roles of N-terminal acetyltransferases
Peer reviewed, Journal article
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Original versionAksnes H, Ree RM, Arnesen TA. Co-translational, post-translational, and non-catalytic roles of N-terminal acetyltransferases. Molecular Cell. 2019;73(6):1097-1114 https://doi.org/10.1016/j.molcel.2019.02.007
Recent studies of N-terminal acetylation have identified new N-terminal acetyltransferases (NATs) and expanded the known functions of these enzymes beyond their roles as ribosome-associated co-translational modifiers. For instance, the identification of Golgi- and chloroplast-associated NATs shows that acetylation of N termini also happens post-translationally. In addition, we now appreciate that some NATs are highly specific; for example, a dedicated NAT responsible for post-translational N-terminal acetylation of actin was recently revealed. Other studies have extended NAT function beyond Nt acetylation, including functions as lysine acetyltransferases (KATs) and non-catalytic roles. Finally, emerging studies emphasize the physiological relevance of N-terminal acetylation, including roles in calorie-restriction-induced longevity and pathological α-synuclein aggregation in Parkinson’s disease. Combined, the NATs rise as multifunctional proteins, and N-terminal acetylation is gaining recognition as a major cellular regulator.