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dc.contributor.authorAksnes, Henrietteen_US
dc.contributor.authorRee, Rasmus Moenen_US
dc.contributor.authorArnesen, Thomasen_US
dc.PublishedAksnes H, Ree RM, Arnesen TA. Co-translational, post-translational, and non-catalytic roles of N-terminal acetyltransferases. Molecular Cell. 2019;73(6):1097-1114eng
dc.description.abstractRecent studies of N-terminal acetylation have identified new N-terminal acetyltransferases (NATs) and expanded the known functions of these enzymes beyond their roles as ribosome-associated co-translational modifiers. For instance, the identification of Golgi- and chloroplast-associated NATs shows that acetylation of N termini also happens post-translationally. In addition, we now appreciate that some NATs are highly specific; for example, a dedicated NAT responsible for post-translational N-terminal acetylation of actin was recently revealed. Other studies have extended NAT function beyond Nt acetylation, including functions as lysine acetyltransferases (KATs) and non-catalytic roles. Finally, emerging studies emphasize the physiological relevance of N-terminal acetylation, including roles in calorie-restriction-induced longevity and pathological α-synuclein aggregation in Parkinson’s disease. Combined, the NATs rise as multifunctional proteins, and N-terminal acetylation is gaining recognition as a major cellular regulator.en_US
dc.rightsAttribution CC BY-NC-NDeng
dc.titleCo-translational, post-translational, and non-catalytic roles of N-terminal acetyltransferasesen_US
dc.typePeer reviewed
dc.typeJournal article
dc.rights.holderCopyright 2019 Elsevier
dc.source.journalMolecular Cell

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