dc.contributor.author | Aksnes, Henriette | en_US |
dc.contributor.author | Ree, Rasmus Moen | en_US |
dc.contributor.author | Arnesen, Thomas | en_US |
dc.date.accessioned | 2020-03-27T15:26:02Z | |
dc.date.available | 2020-03-27T15:26:02Z | |
dc.date.issued | 2019 | |
dc.Published | Aksnes H, Ree RM, Arnesen TA. Co-translational, post-translational, and non-catalytic roles of N-terminal acetyltransferases. Molecular Cell. 2019;73(6):1097-1114 | eng |
dc.identifier.issn | 1097-2765 | |
dc.identifier.issn | 1097-4164 | |
dc.identifier.uri | https://hdl.handle.net/1956/21623 | |
dc.description.abstract | Recent studies of N-terminal acetylation have identified new N-terminal acetyltransferases (NATs) and expanded the known functions of these enzymes beyond their roles as ribosome-associated co-translational modifiers. For instance, the identification of Golgi- and chloroplast-associated NATs shows that acetylation of N termini also happens post-translationally. In addition, we now appreciate that some NATs are highly specific; for example, a dedicated NAT responsible for post-translational N-terminal acetylation of actin was recently revealed. Other studies have extended NAT function beyond Nt acetylation, including functions as lysine acetyltransferases (KATs) and non-catalytic roles. Finally, emerging studies emphasize the physiological relevance of N-terminal acetylation, including roles in calorie-restriction-induced longevity and pathological α-synuclein aggregation in Parkinson’s disease. Combined, the NATs rise as multifunctional proteins, and N-terminal acetylation is gaining recognition as a major cellular regulator. | en_US |
dc.language.iso | eng | eng |
dc.publisher | Elsevier | eng |
dc.rights | Attribution CC BY-NC-ND | eng |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | eng |
dc.title | Co-translational, post-translational, and non-catalytic roles of N-terminal acetyltransferases | en_US |
dc.type | Peer reviewed | |
dc.type | Journal article | |
dc.date.updated | 2019-12-05T14:43:20Z | |
dc.description.version | acceptedVersion | en_US |
dc.rights.holder | Copyright 2019 Elsevier | |
dc.identifier.doi | https://doi.org/10.1016/j.molcel.2019.02.007 | |
dc.identifier.cristin | 1702720 | |
dc.source.journal | Molecular Cell | |