• norsk
    • English
  • English 
    • norsk
    • English
  • Login
View Item 
  •   Home
  • Faculty of Medicine
  • Department of Clinical Dentistry
  • Department of Clinical Dentistry
  • View Item
  •   Home
  • Faculty of Medicine
  • Department of Clinical Dentistry
  • Department of Clinical Dentistry
  • View Item
JavaScript is disabled for your browser. Some features of this site may not work without it.

Microfilaments in cells associated with induced heterotpic bone formation in guinea pigs

Nilsen, Rune
Journal article
Thumbnail
View/Open
APMIS_88.pdf (1.203Mb)
URI
https://hdl.handle.net/1956/2188
Date
1980
Metadata
Show full item record
Collections
  • Department of Clinical Dentistry [231]
Original version
Acta Pathologica, Microbiologica et Immunologica Scandinavica 88(3):129-134  
Abstract
Sera from active chronic hepatitis were used to demonstrate actin microfilaments in cells of a bone-induced model. Demnineralized and freeze-dried allogenic dentine was implanted in the abdominal muscles of Guinea pigs. After 21 and 28 days the tissue was excised and showed: a) resorption areas of the dentine contained dentinoclasts and macrophages. B) osteoid and bone and c) areas of fibroblastic proliferation. Osteoblasts and young osteocytes showed the strongest fluorescent staining. Electron microscopy of these cells demonstrated abundant 5-7 nm microfilaments interpreted as actin in the outer parts and cell projections, in which some microtubules also were observed. Fewer microfilaments were present in mature osteocytes although the cell projections in mineralized bone also showed microfilaments. Microfilaments were also found in some dentinoclasts where the actin was located in projections from the ruffles border protruding into the dentine. The localization in the ruffled border corresponded to the distribution of the fluorescent staining of actin. The high amount of actin in osteoblasts and osteocytes may be correlated to the synthesis and transport of the new matrix components. The microfilaments in the clear sealing zone of dentinoclasts were considered to have a function in the sealing of the ruffled border.
Publisher
APMIS

Contact Us | Send Feedback

Privacy policy
DSpace software copyright © 2002-2019  DuraSpace

Service from  Unit
 

 

Browse

ArchiveCommunities & CollectionsBy Issue DateAuthorsTitlesSubjectsDocument TypesJournalsThis CollectionBy Issue DateAuthorsTitlesSubjectsDocument TypesJournals

My Account

Login

Statistics

View Usage Statistics

Contact Us | Send Feedback

Privacy policy
DSpace software copyright © 2002-2019  DuraSpace

Service from  Unit