dc.contributor.author | Becirovic-Agic, Mediha | en_US |
dc.contributor.author | Jönsson, Sofia | en_US |
dc.contributor.author | Tveitarås, Maria Kathrine | en_US |
dc.contributor.author | Skogstrand, Trude | en_US |
dc.contributor.author | Karlsen, Tine Veronica | en_US |
dc.contributor.author | Liden, Åsa | en_US |
dc.contributor.author | Leh, Sabine Maria | en_US |
dc.contributor.author | Ericsson, Madelene | en_US |
dc.contributor.author | Nilsson, Stefan K. | en_US |
dc.contributor.author | Reed, Rolf K. | en_US |
dc.contributor.author | Hultström, Michael | en_US |
dc.date.accessioned | 2020-04-21T11:33:42Z | |
dc.date.available | 2020-04-21T11:33:42Z | |
dc.date.issued | 2019-05-01 | |
dc.Published | Becirovic-Agic, Jönsson S, Tveitarås MK, Skogstrand T, Karlsen TV, Liden Å, Leh S, Ericsson ME, Nilsson SK, Reed RK, Hultström M. Time course of decompensation after angiotensin II and high-salt diet in Balb/CJ mice suggests pulmonary hypertension-induced cardiorenal syndrome. American Journal of Physiology. Regulatory Integrative and Comparative Physiology. 2019;316(5):R563-R570. | eng |
dc.identifier.issn | 1522-1490 | |
dc.identifier.issn | 0363-6119 | |
dc.identifier.uri | https://hdl.handle.net/1956/21954 | |
dc.description.abstract | The genetic background of a mouse strain determines its susceptibility to disease. C57BL/6J and Balb/CJ are two widely used inbred mouse strains that we found react dramatically differently to angiotensin II and high-salt diet (ANG II + Salt). Balb/CJ show increased mortality associated with anuria and edema formation while C57BL/6J develop arterial hypertension but do not decompensate and die. Clinical symptoms of heart failure in Balb/CJ mice gave the hypothesis that ANG II + Salt impairs cardiac function and induces cardiac remodeling in male Balb/CJ but not in male C57BL/6J mice. To test this hypothesis, we measured cardiac function using echocardiography before treatment and every day for 7 days during treatment with ANG II + Salt. Interestingly, pulsed wave Doppler of pulmonary artery flow indicated increased pulmonary vascular resistance and right ventricle systolic pressure in Balb/CJ mice, already 24 h after ANG II + Salt treatment was started. In addition, Balb/CJ mice showed abnormal diastolic filling indicated by reduced early and late filling and increased isovolumic relaxation time. Furthermore, Balb/CJ exhibited lower cardiac output compared with C57BL/6J even though they retained more sodium and water, as assessed using metabolic cages. Left posterior wall thickness increased during ANG II + Salt treatment but did not differ between the strains. In conclusion, ANG II + Salt treatment causes early restriction of pulmonary flow and reduced left ventricular filling and cardiac output in Balb/CJ, which results in fluid retention and peripheral edema. This makes Balb/CJ a potential model to study the adaptive capacity of the heart for identifying new disease mechanisms and drug targets. | en_US |
dc.language.iso | eng | eng |
dc.publisher | American Physiological Society | eng |
dc.subject | animal model | eng |
dc.subject | congestive heart failure | eng |
dc.subject | pulmonary hypertension | eng |
dc.subject | right-sided heart failure | eng |
dc.title | Time course of decompensation after angiotensin II and high-salt diet in Balb/CJ mice suggests pulmonary hypertension-induced cardiorenal syndrome | en_US |
dc.type | Peer reviewed | |
dc.type | Journal article | |
dc.date.updated | 2020-02-03T12:49:27Z | |
dc.description.version | acceptedVersion | en_US |
dc.rights.holder | Copyright 2019 the American Physiological Society | |
dc.identifier.doi | https://doi.org/10.1152/ajpregu.00373.2018 | |
dc.identifier.cristin | 1709325 | |
dc.source.journal | American Journal of Physiology. Regulatory Integrative and Comparative Physiology | |
dc.source.pagenumber | R563-R570 | |
dc.identifier.citation | American Journal of Physiology. Regulatory Integrative and Comparative Physiology. 2019;316(5):R563-R570. | |
dc.source.volume | 316 | |
dc.source.issue | 5 | |