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dc.contributor.authorKleiven, Øyunnen_US
dc.contributor.authorOmland, Torbjørnen_US
dc.contributor.authorSkadberg, Øyvinden_US
dc.contributor.authorMelberg, Tor Haralden_US
dc.contributor.authorBjørkavoll-Bergseth, Magnusen_US
dc.contributor.authorAuestad, Bjørn Henriken_US
dc.contributor.authorBergseth, Rolfen_US
dc.contributor.authorGreve, Ole Jacoben_US
dc.contributor.authorAakre, Kristin Mobergen_US
dc.contributor.authorØrn, Steinen_US
dc.PublishedKleiven Ø, Omland T, Skadberg Ø, Melberg T, Bjørkavoll-Bergseth M, Auestad BH, Bergseth R, Greve OJ, Aakre A, Ørn S. Race duration and blood pressure are major predictors of exercise-induced cardiac troponin elevation. International Journal of Cardiology. 2019;283:1-8eng
dc.description.abstractBackground: The underlying mechanisms of the exercise-induced increase in cardiac troponins (cTn) are poorly understood. The aim of this study was to identify independent determinants of exercise-induced cTn increase in a large cohort of healthy recreational athletes. Methods: A total of 1002 recreational cyclists without known cardiovascular disease or medication, participating in a 91-km mountain bike race were included. Median age was 47 years and 78% were males. Blood samples were obtained 24 h prior to, and 3 and 24 h after the race. Results: Cardiac TnI concentrations increased markedly from baseline [1.9 (1.6–3.0) ng/L] to 3 h after the race [52.1 (32.4–91.8) ng/L], declining at 24 h after the race [9.9 (6.0–20.0) ng/L]. Similarly, cTnT increased from baseline [3.0 (3.0–4.2) ng/L] to 3 h after the race [35.6 (24.4–54.4) ng/L], followed by a decline at 24 h after the race [10.0 (6.9–15.6) ng/L]. The 99th percentile was exceeded at 3 h after the race in 84% (n = 842) of subjects using the cTnI assay and in 92% (n = 925) of study subjects using the cTnT assay. Shorter race duration and higher systolic blood pressure (SBP) at baseline were highly significant (p < 0.001) independent predictors of exercise-induced cTn increase both in bivariate and multivariable analysis. The age, gender, body mass index, training experience and cardiovascular risk of participants were found to be less consistent predictors. Conclusion: Systolic blood pressure and race duration were consistent predictors of the exercise-induced cTn increase. These variables likely reflect important mechanisms involved in the exercise-induced cTn elevation.en_US
dc.rightsAttribution-NonCommercial-NoDerivs CC BY-NC-NDeng
dc.titleRace duration and blood pressure are major predictors of exercise-induced cardiac troponin elevationen_US
dc.typePeer reviewed
dc.typeJournal article
dc.rights.holderCopyright 2019 Elsevier
dc.source.journalInternational Journal of Cardiology

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