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dc.contributor.authorSaleh, Muhammad G.
dc.contributor.authorRimbault, Daniel
dc.contributor.authorMikkelsen, Mark
dc.contributor.authorOeltzschner, Georg
dc.contributor.authorWang, Anna M
dc.contributor.authorJiang, Dengrong
dc.contributor.authorAlhamud, Ali
dc.contributor.authorNear, Jamie
dc.contributor.authorSchär, Michael
dc.contributor.authorNoeske, Ralph
dc.contributor.authorMurdoch, James B
dc.contributor.authorErsland, Lars
dc.contributor.authorCraven, Alexander R.
dc.contributor.authorDwyer, Gerard Eric
dc.contributor.authorGrüner, Renate
dc.contributor.authorPan, Li
dc.contributor.authorAhn, Sinyeob
dc.contributor.authorEdden, Richard A.E.
dc.date.accessioned2020-05-22T10:57:09Z
dc.date.available2020-05-22T10:57:09Z
dc.date.issued2019
dc.PublishedSaleh, Rimbault, Mikkelsen M, Oeltzschner G, Wang, Jiang, Alhamud, Near, Schär, Noeske R, Murdoch, Ersland L, Craven A.R., Dwyer G, Grüner R, Pan, Ahn, Edden. Multi-vendor standardized sequence for edited magnetic resonance spectroscopy. NeuroImage. 2019;189:425-431eng
dc.identifier.issn1053-8119
dc.identifier.issn1095-9572
dc.identifier.urihttps://hdl.handle.net/1956/22344
dc.description.abstractSpectral editing allows direct measurement of low-concentration metabolites, such as GABA, glutathione (GSH) and lactate (Lac), relevant for understanding brain (patho)physiology. The most widely used spectral editing technique is MEGA-PRESS, which has been diversely implemented across research sites and vendors, resulting in variations in the final resolved edited signal. In this paper, we describe an effort to develop a new universal MEGA-PRESS sequence with HERMES functionality for the major MR vendor platforms with standardized RF pulse shapes, durations, amplitudes and timings. New RF pulses were generated for the universal sequence. Phantom experiments were conducted on Philips, Siemens, GE and Canon 3 T MRI scanners using 32-channel head coils. In vivo experiments were performed on the same six subjects on Philips and Siemens scanners, and on two additional subjects, one on GE and one on Canon scanners. On each platform, edited MRS experiments were conducted with the vendor-native and universal MEGA-PRESS sequences for GABA (TE = 68 ms) and Lac editing (TE = 140 ms). Additionally, HERMES for GABA and GSH was performed using the universal sequence at TE = 80 ms. The universal sequence improves inter-vendor similarity of GABA-edited and Lac-edited MEGA-PRESS spectra. The universal HERMES sequence yields both GABA- and GSH-edited spectra with negligible levels of crosstalk on all four platforms, and with strong agreement among vendors for both edited spectra. In vivo GABA+/Cr, Lac/Cr and GSH/Cr ratios showed relatively low variation between scanners using the universal sequence. In conclusion, phantom and in vivo experiments demonstrate successful implementation of the universal sequence across all four major vendors, allowing editing of several metabolites across a range of TEs.en_US
dc.language.isoengeng
dc.publisherElseviereng
dc.titleMulti-vendor standardized sequence for edited magnetic resonance spectroscopyeng
dc.typePeer reviewed
dc.typeJournal article
dc.date.updated2020-01-30T14:33:51Z
dc.description.versionpublishedVersion
dc.rights.holderCopyright 2019 Elsevier Inc. All rights reserved.eng
dc.identifier.doihttps://doi.org/10.1016/j.neuroimage.2019.01.056
dc.identifier.cristin1667431
dc.source.journalNeuroImage


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