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dc.contributor.authorYazdani, Mazyaren_US
dc.contributor.authorElgstøen, Katja B. Prestøen_US
dc.contributor.authorRootwelt, Helgeen_US
dc.contributor.authorShahdafar, Aboulghassemen_US
dc.contributor.authorUtheim, Øygunn Aassen_US
dc.contributor.authorUtheim, Tor Paaskeen_US
dc.PublishedYazdani M, Elgstøen KBP, Rootwelt H, Shahdafar A, Utheim ØA, Utheim TP. Tear metabolomics in dry eye disease: A review. International Journal of Molecular Sciences. 2019;20(15):3755eng
dc.description.abstractDry eye disease (DED) is a multifactorial syndrome that can be caused by alteration in the quality or quantity of the precorneal tear film. It is considered one of the most common ocular conditions leading patients to seek eye care. The current method for diagnostic evaluations and follow-up examinations of DED is a combination of clinical signs and symptoms determined by clinical tests and questionnaires, respectively. The application of powerful omics technologies has opened new avenues toward analysis of subjects in health and disease. Metabolomics is a new emerging and complementary research discipline to all modern omics in the comprehensive analysis of biological systems. The identification of distinct metabolites and integrated metabolic profiles in patients can potentially inform clinicians at an early stage or during monitoring of disease progression, enhancing diagnosis, prognosis, and the choice of therapy. In ophthalmology, metabolomics has gained considerable attention over the past decade but very limited such studies have been reported on DED. This paper aims to review the application of tear metabolomics in DED.en_US
dc.rightsAttribution CC BYeng
dc.subjectdry eye diseaseeng
dc.titleTear metabolomics in dry eye disease: A reviewen_US
dc.typePeer reviewed
dc.typeJournal article
dc.rights.holderCopyright 2019 The Author(s)
dc.source.journalInternational Journal of Molecular Sciences

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