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dc.contributor.authorTriebner, Kaien_US
dc.contributor.authorMarkevych, Ianaen_US
dc.contributor.authorHustad, Simon Steinaren_US
dc.contributor.authorBenediktsdóttir, Bryndísen_US
dc.contributor.authorForsberg, Bertilen_US
dc.contributor.authorFranklin, Karl A.en_US
dc.contributor.authorGullón Blanco, José Antonioen_US
dc.contributor.authorHolm, Mathiasen_US
dc.contributor.authorJaquemin, Bénédicteen_US
dc.contributor.authorJarvis, Debbieen_US
dc.contributor.authorJõgi, Rainen_US
dc.contributor.authorLeynaert, Bénédicteen_US
dc.contributor.authorLindberg, Evaen_US
dc.contributor.authorMartínez-Moratalla, Jesúsen_US
dc.contributor.authorMuniozguren Agirre, Nereaen_US
dc.contributor.authorPin, Isabelleen_US
dc.contributor.authorSánchez-Ramos, José Luisen_US
dc.contributor.authorHeinrich, Joachimen_US
dc.contributor.authorGomez Real, Franciscoen_US
dc.contributor.authorDadvand, Payamen_US
dc.PublishedTriebner K, Markevych I, Hustad S, Benediktsdóttir B, Forsberg B, Franklin KA, Gullón Blanco JA, Holm M, Jaquemin, Jarvis D, Jõgi R, Leynaert B, Lindberg E, Martínez-Moratalla J, Muniozguren Agirre N, Pin I, Sánchez-Ramos JL, Heinrich J, Gomez Real F, Dadvand P. Residential surrounding greenspace and age at menopause: A 20-year European study (ECRHS). Environment International. 2019;132:105088eng
dc.description.abstractBackground Menopause is associated with a number of adverse health effects and its timing has been reported to be influenced by several lifestyle factors. Whether greenspace exposure is associated with age at menopause has not yet been investigated. Objective To investigate whether residential surrounding greenspace is associated with age at menopause and thus reproductive aging. Methods This longitudinal study was based on the 20-year follow-up of 1955 aging women from a large, population-based European cohort (ECRHS). Residential surrounding greenspace was abstracted as the average of satellite-based Normalized Difference Vegetation Index (NDVI) across a circular buffer of 300 m around the residential addresses of each participant during the course of the study. We applied mixed effects Cox models with centre as random effect, menopause as the survival object, age as time indicator and residential surrounding greenspace as time-varying predictor. All models were adjusted for smoking habit, body mass index, parity, age at menarche, ever-use of contraception and age at completed full-time education as socio-economic proxy. Results An increase of one interquartile range of residential surrounding greenspace was associated with a 13% lower risk of being menopausal (Hazard Ratio: 0.87, 95% Confidence Interval: 0.79–0.95). Correspondingly the predicted median age at menopause was 1.4 years older in the highest compared to the lowest NDVI quartile. Results remained stable after additional adjustment for air pollution and traffic related noise amongst others. Conclusions Living in greener neighbourhoods is associated with older age at menopause and might slow reproductive aging. These are novel findings with broad implications. Further studies are needed to see whether our findings can be replicated in different populations and to explore the potential mechanisms underlying this association.en_US
dc.rightsAttribution-NonCommercial-NoDerivs CC BY-NC-NDeng
dc.rights.uri licenses/by-nc-nd/4.0eng
dc.titleResidential surrounding greenspace and age at menopause: A 20-year European study (ECRHS)en_US
dc.typePeer reviewed
dc.typeJournal article
dc.rights.holderCopyright 2019 The Author(s)
dc.source.journalEnvironment International

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