Show simple item record

dc.contributor.authorKüpers, Leanne K.en_US
dc.contributor.authorMonnereau, Claireen_US
dc.contributor.authorSharp, Gemma C.en_US
dc.contributor.authorYousefi, Paulen_US
dc.contributor.authorSalas, Lucas A.en_US
dc.contributor.authorGhantous, Akramen_US
dc.contributor.authorPage, Christian Magnusen_US
dc.contributor.authorReese, Sarah E.en_US
dc.contributor.authorWilcox, Allen J.en_US
dc.contributor.authorCzamara, Darinaen_US
dc.contributor.authorStarling, Anne P.en_US
dc.contributor.authorNovoloaca, Alexeien_US
dc.contributor.authorLent, Samanthaen_US
dc.contributor.authorRoy, Rituen_US
dc.contributor.authorHoyo, Cathrineen_US
dc.contributor.authorBreton, Carrie V.en_US
dc.contributor.authorAllard, Catherineen_US
dc.contributor.authorJust, Allan C.en_US
dc.contributor.authorBakulski, Kelly M.en_US
dc.contributor.authorHolloway, John W.en_US
dc.contributor.authorEverson, Todd M.en_US
dc.contributor.authorXu, Cheng-Jianen_US
dc.contributor.authorHuang, Rae-Chien_US
dc.contributor.authorvan der Plaat, Diana A.en_US
dc.contributor.authorWielscher, Matthiasen_US
dc.contributor.authorMerid, Simon Kebedeen_US
dc.contributor.authorUllemar, Vilhelminaen_US
dc.contributor.authorRezwan, Faisal I.en_US
dc.contributor.authorLahti, Jarien_US
dc.contributor.authorvan Dongen, Jennyen_US
dc.contributor.authorLangie, Sabine A.S.en_US
dc.contributor.authorRichardson, Tom G.en_US
dc.contributor.authorMagnus, Maria Christineen_US
dc.contributor.authorNohr, Ellen A.en_US
dc.contributor.authorXu, Zonglien_US
dc.contributor.authorDuijts, Liesbethen_US
dc.contributor.authorZhao, Shanshanen_US
dc.contributor.authorZhang, Weimingen_US
dc.contributor.authorPlusquin, Michelleen_US
dc.contributor.authorDeMeo, Dawn L.en_US
dc.contributor.authorSolomon, Oliviaen_US
dc.contributor.authorHeimovaara, Joosje H.en_US
dc.contributor.authorJima, Dereje D.en_US
dc.contributor.authorGao, Luen_US
dc.contributor.authorBustamante, Marionaen_US
dc.contributor.authorPerron, Patriceen_US
dc.contributor.authorWright, Robert O.en_US
dc.contributor.authorHertz-Picciotto, Irvaen_US
dc.contributor.authorZhang, Hongmeien_US
dc.contributor.authorKaragas, Margaret R.en_US
dc.contributor.authorGehring, Ulrikeen_US
dc.contributor.authorMarsit, Carmen J.en_US
dc.contributor.authorBeilin, Lawrence J.en_US
dc.contributor.authorVonk, Judith M.en_US
dc.contributor.authorJarvelin, Marjo-Riittaen_US
dc.contributor.authorBergström, Annaen_US
dc.contributor.authorÖrtqvist, Anne K.en_US
dc.contributor.authorEwart, Susanen_US
dc.contributor.authorVilla, Pia M.en_US
dc.contributor.authorMoore, Sophie E.en_US
dc.contributor.authorWillemsen, Gonnekeen_US
dc.contributor.authorStandaert, Arnout R.L.en_US
dc.contributor.authorHåberg, Siri Eldeviken_US
dc.contributor.authorSørensen, Thorkild I.A.en_US
dc.contributor.authorTaylor, Jack A.en_US
dc.contributor.authorRäikkönen, Katrien_US
dc.contributor.authorYang, Ivana V.en_US
dc.contributor.authorKechris, Katerinaen_US
dc.contributor.authorNawrot, Tim S.en_US
dc.contributor.authorSilver, Matt J.en_US
dc.contributor.authorGong, Yun Yunen_US
dc.contributor.authorRichiardi, Lorenzoen_US
dc.contributor.authorKogevinas, Manolisen_US
dc.contributor.authorLitonjua, Augusto A.en_US
dc.contributor.authorEskenazi, Brendaen_US
dc.contributor.authorHuen, Karenen_US
dc.contributor.authorMbarek, Hamdien_US
dc.contributor.authorMaguire, Rachel L.en_US
dc.contributor.authorDwyer, Terenceen_US
dc.contributor.authorVrijheid, Martineen_US
dc.contributor.authorBouchard, Luigien_US
dc.contributor.authorBaccarelli, Andrea A.en_US
dc.contributor.authorCroen, Lisa A.en_US
dc.contributor.authorKarmaus, Wilfrieden_US
dc.contributor.authorAnderson, Deniseen_US
dc.contributor.authorde Vries, Maaikeen_US
dc.contributor.authorSebert, Sylvainen_US
dc.contributor.authorKere, Juhaen_US
dc.contributor.authorKarlsson, Roberten_US
dc.contributor.authorArshad, Syed Hasanen_US
dc.contributor.authorHämäläinen, Esaen_US
dc.contributor.authorRoutledge, Michael N.en_US
dc.contributor.authorBoomsma, Dorret I.en_US
dc.contributor.authorFeinberg, Andrew P.en_US
dc.contributor.authorNewschaffer, Craig J.en_US
dc.contributor.authorGovarts, Evaen_US
dc.contributor.authorMoisse, Matthieuen_US
dc.contributor.authorFallin, M. Danieleen_US
dc.contributor.authorMelén, Eriken_US
dc.contributor.authorPrentice, Andrew M.en_US
dc.contributor.authorKajantie, Eeroen_US
dc.contributor.authorAlmqvist, Catarinaen_US
dc.contributor.authorOken, Emilyen_US
dc.contributor.authorDabelea, Danaen_US
dc.contributor.authorBoezen, H. Marikeen_US
dc.contributor.authorMelton, Philip E.en_US
dc.contributor.authorWright, Rosalind J.en_US
dc.contributor.authorKoppelman, Gerard H.en_US
dc.contributor.authorTrevisi, Letiziaen_US
dc.contributor.authorHivert, Marie-Franceen_US
dc.contributor.authorSunyer, Jordien_US
dc.contributor.authorMunthe-Kaas, Monica Chengen_US
dc.contributor.authorMurphy, Susan K.en_US
dc.contributor.authorCorpeleijn, Evaen_US
dc.contributor.authorWiemels, Joseph L.en_US
dc.contributor.authorHolland, Ninaen_US
dc.contributor.authorHerceg, Zdenkoen_US
dc.contributor.authorBinder, Elisabeth B.en_US
dc.contributor.authorDavey Smith, Georgeen_US
dc.contributor.authorJaddoe, Vincent V.W.en_US
dc.contributor.authorLie, Rolv T.en_US
dc.contributor.authorNystad, Wencheen_US
dc.contributor.authorLondon, Stephanie J.en_US
dc.contributor.authorLawlor, Debbie A.en_US
dc.contributor.authorRelton, Caroline L.en_US
dc.contributor.authorSnieder, Harolden_US
dc.contributor.authorFelix, Janine F.en_US
dc.PublishedKüpers LK, Monnereau C, Sharp GC, Yousefi P, Salas LA, Ghantous A, Page CM, Reese SE, Wilcox AJ, Czamara D, Starling AP, Novoloaca A, Lent, Roy R, Hoyo C, Breton CV, Allard C, Just AC, Bakulski KM, Holloway JW, Everson TM, Xu C, Huang R, van der Plaat, Wielscher M, Merid SK, Ullemar V, Rezwan FI, Lahti J, van Dongen, Langie SA, Richardson, Magnus MC, Nohr EA, Xu Z, Duijts L, Zhao S, Zhang W, Plusquin M, DeMeo DL, Solomon, Heimovaara, Jima DD, Gao L, Bustamante M, Perron P, Wright, Hertz-Picciotto I, Zhang H, Karagas MR, Gehring U, Marsit CJ, Beilin LJ, Vonk JM, Jarvelin M, Bergström A, Örtqvist, Ewart S, Villa PM, Moore, Willemsen G, Standaert, Håberg SE, Sørensen TI, Taylor JA, Räikkönen K, Yang, Kechris, Nawrot TS, Silver, Gong YY, Richiardi L, Kogevinas M, Litonjua AA, Eskenazi B, Huen K, Mbarek H, Maguire RL, Dwyer T, Vrijheid M, Bouchard L, Baccarelli AA, Croen, Karmaus W, Anderson D, de Vries, Sebert S, Kere J, Karlsson R, Arshad SH, Hämäläinen E, Routledge MN, Boomsma DI, Feinberg AP, Newschaffer, Govarts E, Moisse M, Fallin MD, Melén E, Prentice AM, Kajantie E, Almqvist C, Oken E, Dabelea D, Boezen HM, Melton PE, Wright RJ, Koppelman GH, Trevisi, Hivert M, Sunyer J, Munthe-Kaas MC, Murphy SK, Corpeleijn E, Wiemels JL, Holland N, Herceg Z, Binder EB, Davey Smith G, Jaddoe VV, Lie RT, Nystad W, London SJ, Lawlor DA, Relton CL, Snieder H, Felix JF. Meta-analysis of epigenome-wide association studies in neonates reveals widespread differential DNA methylation associated with birthweight. Nature Communications. 2019;10:1893eng
dc.description.abstractBirthweight is associated with health outcomes across the life course, DNA methylation may be an underlying mechanism. In this meta-analysis of epigenome-wide association studies of 8,825 neonates from 24 birth cohorts in the Pregnancy And Childhood Epigenetics Consortium, we find that DNA methylation in neonatal blood is associated with birthweight at 914 sites, with a difference in birthweight ranging from −183 to 178 grams per 10% increase in methylation (PBonferroni < 1.06 x 10−7). In additional analyses in 7,278 participants, <1.3% of birthweight-associated differential methylation is also observed in childhood and adolescence, but not adulthood. Birthweight-related CpGs overlap with some Bonferroni-significant CpGs that were previously reported to be related to maternal smoking (55/914, p = 6.12 x 10−74) and BMI in pregnancy (3/914, p = 1.13x10−3), but not with those related to folate levels in pregnancy. Whether the associations that we observe are causal or explained by confounding or fetal growth influencing DNA methylation (i.e. reverse causality) requires further research.en_US
dc.publisherNature Researcheng
dc.rightsAttribution CC BYeng
dc.titleMeta-analysis of epigenome-wide association studies in neonates reveals widespread differential DNA methylation associated with birthweighten_US
dc.typePeer reviewed
dc.typeJournal article
dc.rights.holderCopyright 2019 The Author(s)
dc.source.journalNature Communications

Files in this item


This item appears in the following Collection(s)

Show simple item record

Attribution CC BY
Except where otherwise noted, this item's license is described as Attribution CC BY