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dc.contributor.authorLee, Yunsungen_US
dc.contributor.authorSun, Dianjianyien_US
dc.contributor.authorOri, Anil P.S.en_US
dc.contributor.authorLu, Ake T.en_US
dc.contributor.authorSeeboth, Anneen_US
dc.contributor.authorHarris, Sarah E.en_US
dc.contributor.authorDeary, Ian J.en_US
dc.contributor.authorMarioni, Riccardo E.en_US
dc.contributor.authorSørensen, Metteen_US
dc.contributor.authorMengel-From, Jonasen_US
dc.contributor.authorHjelmborg, Jacoben_US
dc.contributor.authorChristensen, Kaareen_US
dc.contributor.authorWilson, James G.en_US
dc.contributor.authorLevy, Danielen_US
dc.contributor.authorReiner, Alex P.en_US
dc.contributor.authorChen, Weien_US
dc.contributor.authorLi, Shengxuen_US
dc.contributor.authorHarris, Jennifer Ruthen_US
dc.contributor.authorMagnus, Peren_US
dc.contributor.authorAviv, Abrahamen_US
dc.contributor.authorJugessur, Astananden_US
dc.contributor.authorHorvath, Steveen_US
dc.PublishedLee Y, Sun, Ori AP, Lu AT, Seeboth, Harris SE, Deary IJ, Marioni RE, Sørensen M, Mengel-From J, Hjelmborg J, Christensen K, Wilson JG, Levy D, Reiner AP, Chen W, Li, Harris J, Magnus P, Aviv A, Jugessur A, Horvath S. Epigenome-wide association study of leukocyte telomere length. Aging. 2019;11(16):5876-5894eng
dc.description.abstractTelomere length is associated with age-related diseases and is highly heritable. It is unclear, however, to what extent epigenetic modifications are associated with leukocyte telomere length (LTL). In this study, we conducted a large-scale epigenome-wide association study (EWAS) of LTL using seven large cohorts (n=5,713) – the Framingham Heart Study, the Jackson Heart Study, the Women’s Health Initiative, the Bogalusa Heart Study, the Lothian Birth Cohorts of 1921 and 1936, and the Longitudinal Study of Aging Danish Twins. Our stratified analysis suggests that EWAS findings for women of African ancestry may be distinct from those of three other groups: males of African ancestry, and males and females of European ancestry. Using a meta-analysis framework, we identified DNA methylation (DNAm) levels at 823 CpG sites to be significantly associated (P<1E-7) with LTL after adjusting for age, sex, ethnicity, and imputed white blood cell counts. Functional enrichment analyses revealed that these CpG sites are near genes that play a role in circadian rhythm, blood coagulation, and wound healing. Weighted correlation network analysis identified four co-methylation modules associated with LTL, age, and blood cell counts. Overall, this study reveals highly significant relationships between two hallmarks of aging: telomere biology and epigenetic changes.en_US
dc.publisherImpact Journalseng
dc.rightsAttribution CC BYeng
dc.titleEpigenome-wide association study of leukocyte telomere lengthen_US
dc.typePeer reviewed
dc.typeJournal article
dc.rights.holderCopyright: Lee et al.

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