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dc.contributor.authorO`Connell, Kevinen_US
dc.contributor.authorShadrin, Alexey A.en_US
dc.contributor.authorSmeland, Olav Bjerkehagenen_US
dc.contributor.authorBahrami, Shahramen_US
dc.contributor.authorFrei, Oleksandren_US
dc.contributor.authorBettella, Francescoen_US
dc.contributor.authorKrull, Florianen_US
dc.contributor.authorFan, Chun C.en_US
dc.contributor.authorAskeland, Ragna Buggeen_US
dc.contributor.authorKnudsen, Gun Peggy Strømstaden_US
dc.contributor.authorHalmøy, Anneen_US
dc.contributor.authorSteen, Nils Eielen_US
dc.contributor.authorUeland, Torillen_US
dc.contributor.authorWalters, Bragien_US
dc.contributor.authorDavíðsdóttir, Katrínen_US
dc.contributor.authorHaraldsdóttir, Gyda S.en_US
dc.contributor.authorGuðmundsson, Ólafuren_US
dc.contributor.authorStefansson, Hreinnen_US
dc.contributor.authorReichborn-Kjennerud, Teden_US
dc.contributor.authorHaavik, Janen_US
dc.contributor.authorDale, Anders M.en_US
dc.contributor.authorStefánsson, Kárien_US
dc.contributor.authorDjurovic, Srdjanen_US
dc.contributor.authorAndreassen, Ole Andreasen_US
dc.date.accessioned2020-07-03T08:32:18Z
dc.date.available2020-07-03T08:32:18Z
dc.date.issued2020
dc.PublishedO`Connell K, Shadrin AA, Smeland OB, Bahrami S, Frei O, Bettella F, Krull F, Fan CC, Askeland RB, Knudsen GPS, Halmøy A, Steen NE, Ueland T, Walters B, Davíðsdóttir K, Haraldsdóttir GS, Guðmundsson Ó, Stefansson H, Reichborn-Kjennerud T, Haavik J, Dale AM, Stefánsson K, Djurovic S, Andreassen OA. Identification of Genetic Loci Shared Between Attention-Deficit/Hyperactivity Disorder, Intelligence, and Educational Attainment. Biological Psychiatry. 2020;87(12):1052-1062eng
dc.identifier.issn1873-2402
dc.identifier.issn0006-3223
dc.identifier.urihttps://hdl.handle.net/1956/23295
dc.description.abstractBackground: Attention-deficit/hyperactivity disorder (ADHD) is a neurodevelopmental disorder that is consistently associated with lower levels of educational attainment. A recent large genome-wide association study identified common gene variants associated with ADHD, but most of the genetic architecture remains unknown. Methods: We analyzed independent genome-wide association study summary statistics for ADHD (19,099 cases and 34,194 controls), educational attainment (N = 842,499), and general intelligence (N = 269,867) using a conditional/conjunctional false discovery rate (FDR) statistical framework that increases power of discovery by conditioning the FDR on overlapping associations. The genetic variants identified were characterized in terms of function, expression, and biological processes. Results: We identified 58 linkage disequilibrium–independent ADHD-associated loci (conditional FDR < 0.01), of which 30 were shared between ADHD and educational attainment or general intelligence (conjunctional FDR < 0.01) and 46 were novel risk loci for ADHD. Conclusions: These results expand on previous genetic and epidemiological studies and support the hypothesis of a shared genetic basis between these phenotypes. Although the clinical utility of the identified loci remains to be determined, they can be used as resources to guide future studies aiming to disentangle the complex etiologies of ADHD, educational attainment, and general intelligence.en_US
dc.language.isoengeng
dc.publisherElseviereng
dc.rightsAttribution-NonCommercial-NoDerivs CC BY-NC-NDeng
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/eng
dc.titleIdentification of Genetic Loci Shared Between Attention-Deficit/Hyperactivity Disorder, Intelligence, and Educational Attainmenten_US
dc.typePeer reviewed
dc.typeJournal article
dc.date.updated2020-01-14T12:08:13Z
dc.description.versionacceptedVersionen_US
dc.rights.holderCopyright 2019 Society of Biological Psychiatry
dc.identifier.doihttps://doi.org/10.1016/j.biopsych.2019.11.015
dc.identifier.cristin1772361
dc.source.journalBiological Psychiatry
dc.source.pagenumber1052-1062
dc.identifier.citationBiological Psychiatry. 2020;87(12):1052-1062
dc.source.volume87
dc.source.issue12


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